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Cyclin-dependent kinases regulatory subunit 1

NameCyclin-dependent kinases regulatory subunit 1
Synonyms
  • CKS-1
  • CKS1
Gene NameCKS1B
OrganismHuman
Amino acid sequence
>lcl|BSEQ0013183|Cyclin-dependent kinases regulatory subunit 1
MSHKQIYYSDKYDDEEFEYRHVMLPKDIAKLVPKTHLMSESEWRNLGVQQSQGWVHYMIH
EPEPHILLFRRPLPKKPKK
Number of residues79
Molecular Weight9660.14
Theoretical pINot Available
GO Classification
Functions
  • cyclin-dependent protein serine/threonine kinase regulator activity
Processes
  • cell division
  • cell proliferation
  • mitotic cell cycle
  • G1/S transition of mitotic cell cycle
  • regulation of cyclin-dependent protein serine/threonine kinase activity
Components
  • nucleoplasm
General FunctionCyclin-dependent protein serine/threonine kinase regulator activity
Specific FunctionBinds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein IDNot Available
UniProtKB IDP61024
UniProtKB Entry NameCKS1_HUMAN
Cellular LocationNot Available
Gene sequence
>lcl|BSEQ0013184|Cyclin-dependent kinases regulatory subunit 1 (CKS1B)
ATGTCGCACAAACAAATTTACTATTCGGACAAATACGACGACGAGGAGTTTGAGTATCGA
CATGTCATGCTGCCCAAGGACATAGCCAAGCTGGTCCCTAAAACCCATCTGATGTCTGAA
TCTGAATGGAGGAATCTTGGCGTTCAGCAGAGTCAGGGATGGGTCCATTATATGATCCAT
GAACCAGAACCTCACATCTTGCTGTTCCGGCGCCCACTACCCAAGAAACCAAAGAAATGA
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:19083
Chromosome Location1
LocusNot Available
References
  1. Richardson HE, Stueland CS, Thomas J, Russell P, Reed SI: Human cDNAs encoding homologs of the small p34Cdc28/Cdc2-associated protein of Saccharomyces cerevisiae and Schizosaccharomyces pombe. Genes Dev. 1990 Aug;4(8):1332-44. 2227411
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  3. Burkard TR, Planyavsky M, Kaupe I, Breitwieser FP, Burckstummer T, Bennett KL, Superti-Furga G, Colinge J: Initial characterization of the human central proteome. BMC Syst Biol. 2011 Jan 26;5:17. doi: 10.1186/1752-0509-5-17. 21269460
  4. Van Damme P, Lasa M, Polevoda B, Gazquez C, Elosegui-Artola A, Kim DS, De Juan-Pardo E, Demeyer K, Hole K, Larrea E, Timmerman E, Prieto J, Arnesen T, Sherman F, Gevaert K, Aldabe R: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. Proc Natl Acad Sci U S A. 2012 Jul 31;109(31):12449-54. doi: 10.1073/pnas.1210303109. Epub 2012 Jul 18. 22814378
  5. Arvai AS, Bourne Y, Hickey MJ, Tainer JA: Crystal structure of the human cell cycle protein CksHs1: single domain fold with similarity to kinase N-lobe domain. J Mol Biol. 1995 Jun 23;249(5):835-42. 7791211
  6. Bourne Y, Watson MH, Hickey MJ, Holmes W, Rocque W, Reed SI, Tainer JA: Crystal structure and mutational analysis of the human CDK2 kinase complex with cell cycle-regulatory protein CksHs1. Cell. 1996 Mar 22;84(6):863-74. 8601310