374 Cadmium fluoride Cadmium fluoride is a water-insoluble chemical compound of cadmium used in oxygen-sensitive applications, such as the production of metallic alloys. Cadmium is a transition metal and chemical element with the symbol Cd and atomic number 48. It is found naturally in the earth's crust, though rarely on it's own. (L6, L467) 7790-79-6 10130045 CdF2 151.900160 White-grey crystals. 1110°C 1748°C Oral (L6) ; inhalation (L6) ; dermal (L6) Cadmium initially binds to metallothionein and is transported to the kidney. Toxic effects are observed once the concentration of cadmium exceeds that of available metallothionein, and it has also been shown that the cadmium-metallothionein complex may be damaging. Accumulation of cadmium in the kidney results in increased excretion of vital low and high weight molecular proteins. Cadmium is a high affinity zinc analog and can interfere in its biological processes. It also binds to and activates the estrogen receptor, likely stimulating the growth of certain types of cancer cells and causing other estrogenic effects, such as reproductive dysfunction. Cadmium causes cell apoptosis by activating mitogen-activated protein kinases. (L8, A18, A19, A28) Cadmium is absorbed from oral, inhalation, and dermal routes. Cadmium initially binds to metallothionein and albumin and is transported mainly to the kidney and liver. Toxic effects are observed once the concentration of cadmium exceeds that of available metallothionein, and it has also been shown that the cadmium-metallothionein complex may be damaging. Cadmium is not known to undergo any direct metabolic conversion and is excreted unchanged, mainly in the urine. (L6) 1, carcinogenic to humans. (L135) Cadmium fluoride is used in the production of metallic alloys, for electronic and optical applications and as a starting material for laser crystals. (L467) Acute Inhalation: 0.00003 mg/m3 (L134) Chronic Inhalation: 0.00001 mg/m3 (L134) Intermediate Oral: 0.0005 mg/kg/day (L134) Chronic Oral: 0.0001 mg/kg/day (L134) Chronic exposure to cadmium fumes can cause chemical pneumonitis, pulmonary edema, and lung diseases such as bronchitis and emphysema. Cadmium also accumulates in the kidneys, causing permanent damage. Loss of bone density also occurs. (L6) Acute inhalation of cadmium fumes results in metal fume fever, which is characterized by chills, fever, headache, weakness, dryness of the nose and throat, chest pain, and coughing. Ingestion of cadmium causes vomiting and diarrhea. (L6) Cadmium poisoning is treated by removal from exposure and supportive care. If ingested, induced vomiting or gastric lavage may be performed. (L139) 2009-03-06T18:58:38Z 2014-12-24T20:21:43Z Metallothionein-2 (P02795) Metallothionein-1G (P13640) Metallothionein-1H (P80294) Metallothionein-3 (P25713) Metallothionein-1F (P04733) Metallothionein-1E (P04732) Metallothionein-1X (P80297) Metallothionein-1A (P04731) Metallothionein-1B (P07438) Metallothionein-1M (Q8N339) Metallothionein-4 (P47944) Metallothionein-1L (Q93083) Serum albumin (P02768) (L6, L92) Cadmium fluoride true Metallothionein-2 (P02795) Metallothionein-1G (P13640) Metallothionein-1H (P80294) Metallothionein-3 (P25713) Metallothionein-1F (P04733) Metallothionein-1E (P04732) Metallothionein-1X (P80297) Metallothionein-1A (P04731) Metallothionein-1B (P07438) Metallothionein-1M (Q8N339) Metallothionein-4 (P47944) Metallothionein-1L (Q93083) Serum albumin (P02768) (L6, L92) F[Cd]F CdF2 InChI=1S/Cd.2FH/h;2*1H/q+2;;/p-2 InChIKey=LVEULQCPJDDSLD-UHFFFAOYSA-L 150.408 151.900164531 Exogenous Solid