2492 (2S,4R,5S)-Muscarine Main toxic constituent of the fly fungus Amanita muscaria and various Inocybe species (2S,4R,5S)-Muscarine belongs to the family of Oxolanes. These are organic compounds containing an oxolane (tetrahydrofuran) ring, which is a saturated aliphatic five-member ring containing one oxygen and five carbon atoms. 300-54-9 5079496 C9H20NO2 White powder. Oral, dermal, inhalation, and parenteral (contaminated drugs). (A3101) Muscarine is a competitive inhibitor. It mimics the action of the neurotransmitter acetylcholine at acetylcholine receptors. (L1011) No indication of carcinogenicity to humans (not listed by IARC). Muscarine is only a trace compound in the fly agaric Amanita muscaria; the pharmacologically more relevant compound from this mushroom is muscimol. Mushrooms in the genera Entoloma and Mycena have also been found to contain levels of muscarine which can be dangerous if ingested. Muscarine has been found in harmless trace amounts in Boletus, Hygrocybe, Lactarius and Russula. (L1011) Intoxication generally subsides within 2 hours. Death is rare, but may result from cardiac or respiratory failure in severe cases. (L1011) Muscarine poisoning is characterized by increased salivation, sweating (perspiration), and tearflow (lacrimation) within 15 to 30 minutes after ingestion of the mushroom. With large doses, these symptoms may be followed by abdominal pain, severe nausea, diarrhea, blurred vision, and labored breathing. (L1011) The specific antidote is atropine. (L1011) 2009-07-03T20:53:35Z 2014-12-24T20:25:31Z http://en.wikipedia.org/wiki/Muscarine C07473 522933 D009116 Muscarine true [H][C@@]1(C)O[C@]([H])(C[N+](C)(C)C)C[C@@]1([H])O C9H20NO2 InChI=1S/C9H20NO2/c1-7-9(11)5-8(12-7)6-10(2,3)4/h7-9,11H,5-6H2,1-4H3/q+1/t7-,8-,9+/m0/s1 InChIKey=UQOFGTXDASPNLL-XHNCKOQMSA-N 174.2601 174.148855309 Exogenous Solid HMDB29936 4255959