2512 Phallacidin Phallacidin is one of a group of toxins from the death cap (Amanita phalloides) known as phallotoxins. The phallotoxins consist of at least seven compounds, all of which have seven similar peptide rings, isolated from the death cap (Amanita phalloides). (L996) 26645-35-2 44134886 2570.9300000000003 Clear solution. >10 mg/mL Oral, dermal, inhalation, and parenteral (contaminated drugs). (A3101) Phallotoxins bind actin, preventing its depolymerization and poisoning the cell. They bind specifically at the interface between F-actin subunits, locking adjacent subunits together. This leads to a decrease in the rate constant for the dissociation of actin subunits from filament ends, which essentially stabilizes actin filaments through the prevention of filament depolymerization. Moreover, they inhibit the ATP hydrolysis activity of F-actin. (L1183, A2465) Free toxin may be removed by opsonization via the reticuloendothelial system (primarily the liver and kidneys) or it may be degraded through cellular internalization via the lysosomes. Lysosomes are membrane-enclosed organelles that contain an array of digestive enzymes, including several proteases. LD50: 1.5 mg/kg (Mouse) (T258) No indication of carcinogenicity to humans (not listed by IARC). Phallisin is one of a group of toxins from the death cap (Amanita phalloides) known as phallotoxins. (L996) Liver lesions, tachycardia, hypoglycemia, hypotension and electrolyte imbalance with acid- base disturbance (L1160). Hypovolemic shock; Gastrointestinal symptoms occur after a latent period and include abdominal pain, vomiting, and watery diarrhea. Neurologic symptoms are related to hepatic failure and may include encephalopathy, somnolence, confusion, coma and seizures (L1160). Consider gastric lavage and activated charcoal. (A678) 2009-07-03T21:46:56Z 2014-12-24T20:25:33Z A0A023UBY3 52732 C017613 Phallacidin true CC(C)C1N=C(O)C(CC(C)(O)CO)N=C(O)C2CC3=C(NC4=CC=CC=C34)SCC(N=C(O)N3CC(O)CC3C(O)=NC(C)C(O)=N2)C(=O)C(N=C1O)C(O)C(O)=O C37H50N8O13S InChI=1/C37H50N8O13S/c1-15(2)25-33(54)44-26(28(49)35(55)56)27(48)23-13-59-34-19(18-7-5-6-8-20(18)41-34)10-21(30(51)40-22(31(52)43-25)11-37(4,58)14-46)39-29(50)16(3)38-32(53)24-9-17(47)12-45(24)36(57)42-23/h5-8,15-17,21-26,28,41,46-47,49,58H,9-14H2,1-4H3,(H,38,53)(H,39,50)(H,40,51)(H,42,57)(H,43,52)(H,44,54)(H,55,56) InChIKey=BYPSVXOZIRQBFU-UHFFFAOYNA-N 846.904 846.321804416 Exogenous Liquid 26540893 Phallacidin.jpg image/jpeg 75861 2014-10-14T18:12:32Z BSEQ0008417