2558 Kaliotoxin-2 Kaliotoxin-2 is a peptide toxin produced by the Sahara scorpion (Androctonus australis). It is a neurotoxin that binds to voltage-gated and calcium-activated potassium channels. (L1053) 159605-22-8 6392.8399999999965 Clear solution. >10 mg/mL Injection (sting/bite) (L1813) Kaliotoxin is a neurotoxin that binds to voltage-gated and calcium-activated potassium channels. It binds to the extracellular surface and blocks the channel, affecting the regulation of processes such as neurotransmitter release, heart rate, insulin secretion, smooth muscle contraction. (L1053) Free toxin may be removed by opsonization via the reticuloendothelial system (primarily the liver and kidneys) or it may be degraded through cellular internalization via the lysosomes. Lysosomes are membrane-enclosed organelles that contain an array of digestive enzymes, including several proteases. LD50: 0.32 mg/kg (Subcutaneous, Mouse) (T255) No indication of carcinogenicity to humans (not listed by IARC). Kaliotoxin-2 is a peptide toxin produced by the Sahara scorpion (Androctonus australis). (L1053) Kaliotoxin is neurotoxic. (L1053) Scorpion stings cause tingling or burning at the site of the sting. In more severe cases, symptoms may include spasm in the throat, feeling of thick tongue, restlessness, muscular fibrillation, abdominal cramps, convulsions, incontinence, hypertension, hypotension, oliguria, cardiac arrhythmias, pulmonary edema, and respiratory failure. (T156) An antivenom exists for Androctonus stings. (L1044) 2009-07-03T22:19:07Z 2014-12-24T20:25:39Z P45696 true Exogenous Liquid BSEQ0008446