2753 T3D2711 Fluconazole Fluconazole is only found in individuals that have used or taken this drug. It is a triazole antifungal agent that is used to treat oropharyngeal candidiasis and cryptococcal meningitis in AIDS. Fluconazole interacts with 14-&alpha; demethylase, a cytochrome P-450 enzyme necessary to convert lanosterol to ergosterol. As ergosterol is an essential component of the fungal cell membrane, inhibition of its synthesis results in increased cellular permeability causing leakage of cellular contents. Fluconazole may also inhibit endogenous respiration, interact with membrane phospholipids, inhibit the transformation of yeasts to mycelial forms, inhibit purine uptake, and impair triglyceride and/or phospholipid biosynthesis. 86386-73-4 3365 C13H12F2N6O 306.104060 White powder. 138-140°C 1 mg/L Intravenous, Oral Fluconazole interacts with 14-&alpha; demethylase, a cytochrome P-450 enzyme necessary to convert lanosterol to ergosterol. As ergosterol is an essential component of the fungal cell membrane, inhibition of its synthesis results in increased cellular permeability causing leakage of cellular contents. Fluconazole may also inhibit endogenous respiration, interact with membrane phospholipids, inhibit the transformation of yeasts to mycelial forms, inhibit purine uptake, and impair triglyceride and/or phospholipid biosynthesis. Hepatic Route of Elimination: In normal volunteers, fluconazole is cleared primarily by renal excretion, with approximately 80% of the administered dose appearing in the urine as unchanged drug. Half Life: 30 hours (range 20-50 hours) No indication of carcinogenicity to humans (not listed by IARC). For the treatment of fungal infections. Symptoms of overdose include hallucinations and paranoid behavior. In the event of overdose, symptomatic treatment (with supportive measures and gastric lavage if clinically indicated) should be instituted. (L1712) 2009-07-21T20:26:16Z 2014-12-24T20:25:50Z Fluconazole 46081 Fluconazole DB00196 TPF true OC(CN1C=NC=N1)(CN1C=NC=N1)C1=C(F)C=C(F)C=C1 C13H12F2N6O InChI=1S/C13H12F2N6O/c14-10-1-2-11(12(15)3-10)13(22,4-20-8-16-6-18-20)5-21-9-17-7-19-21/h1-3,6-9,22H,4-5H2 InChIKey=RFHAOTPXVQNOHP-UHFFFAOYSA-N 306.2708 306.104065446 Exogenous Solid 0.4 HMDB14342 CHEMBL106 3248 <p><a href="http://www.drugsyn.org/Fluconazole.htm">DrugSyn.org</a></p>