2761 Temazepam Temazepam is only found in individuals that have used or taken this drug. It is a benzodiazepine that acts as a gamma-aminobutyric acid modulator and anti-anxiety agent. [PubChem]Benzodiazepines bind nonspecifically to benzodiazepine receptors, which affects muscle relaxation, anticonvulsant activity, motor coordination, and memory. As benzodiazepine receptors are thought to be coupled to gamma-aminobutyric acid-A (GABA_A) receptors, this enhances the effects of GABA by increasing GABA affinity for the GABA receptor. Binding of the inhibitory neurotransmitter GABA to the site opens the chloride channel, resulting in a hyperpolarized cell membrane that prevents further excitation of the cell. 846-50-4 5391 C16H13ClN2O2 300.066550 White powder. 119-121°C 164 mg/L Oral, well absorbed, minimal first-pass metabolism. Benzodiazepines bind nonspecifically to benzodiazepine receptors, which affects muscle relaxation, anticonvulsant activity, motor coordination, and memory. As benzodiazepine receptors are thought to be coupled to gamma-aminobutyric acid-A (GABA_A) receptors, this enhances the effects of GABA by increasing GABA affinity for the GABA receptor. Binding of the inhibitory neurotransmitter GABA to the site opens the chloride channel, resulting in a hyperpolarized cell membrane that prevents further excitation of the cell. Hepatic. Temazepam is completely metabolized through conjugation prior to excretion. The major metabolite is the O-conjugate of temazepam (90%). Route of Elimination: Temazepam was completely metabolized through conjugation prior to excretion; 80% to 90% of the dose appeared in the urine. Half Life: 10-20 hours LD50: 1963 mg/kg (oral, mice) (L1338) LD50: 1833 mg/kg (oral, rat) (L1338) LD50: >2400 mg/kg (oral, rabbit) (L1338) 3, not classifiable as to its carcinogenicity to humans. (L135) Officially indicated for severe insomnia and other severe or disabling sleep disorders. For the short-term treatment of insomnia (generally 7-10 days). They cause slurred speech, disorientation and "drunken" behavior. They are physically and psychologically addictive. If the patient is conscious, vomiting should be induced mechanically or with emetics. Gastric lavage should be employed utilizing concurrently a cuffed endotracheal tube if the patient is unconscious to prevent aspiration and pulmonary complications. Maintenance of adequate pulmonary ventilation is essential. The use of pressor agents intravenously may be necessary to combat hypotension. Fluids should be administered intravenously to encourage diuresis. (L1712) 2009-07-21T20:26:20Z 2014-12-24T20:25:50Z Temazepam C07125 195909 Temazepam DB00231 true CN1C2=C(C=C(Cl)C=C2)C(=NC(O)C1=O)C1=CC=CC=C1 C16H13ClN2O2 InChI=1/C16H13ClN2O2/c1-19-13-8-7-11(17)9-12(13)14(18-15(20)16(19)21)10-5-3-2-4-6-10/h2-9,15,20H,1H3 InChIKey=SEQDDYPDSLOBDC-UHFFFAOYNA-N 300.74 300.066555377 Exogenous Solid 2.19 HMDB14376 CHEMBL967 5198