2785 T3D2743 Mitomycin Mitomycin is only found in individuals that have used or taken this drug. It is an antineoplastic antibiotic produced by Streptomyces caespitosus. It is one of the bi- or tri-functional alkylating agents causing cross-linking of DNA and inhibition of DNA synthesis. Mitomycin is activated in vivo to a bifunctional and trifunctional alkylating agent. Binding to DNA leads to cross-linking and inhibition of DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. 50-07-7 5746 C15H18N4O5 334.127720 White powder. >360°C 534°C Soluble (8430 mg/L) Intravesical, erratic, intravenous. Mitomycin is activated in vivo to a bifunctional and trifunctional alkylating agent. Binding to DNA leads to cross-linking and inhibition of DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. Primarily hepatic, some in various other tissues. Route of Elimination: Approximately 10% of a dose of mitomycin is excreted unchanged in the urine. Half Life: 8-48 min LD50: 23 mg/kg (Oral, Mouse) (A308) LD50: 30 mg/kg (Oral, Rat) (A308) 2B, possibly carcinogenic to humans. (L135) For treatment of malignant neoplasm of lip, oral cavity, pharynx, digestive organs, peritoneum, female breast, and urinary bladder. Also used as an adjunct to ab externo glaucoma surgery. Mitomycin C causes delayed bone marrow toxicity and therefore it is usually administered at 6-weekly intervals. Prolonged use may result in permanent bone-marrow damage. It may also cause lung fibrosis and renal damage. 2009-07-21T20:26:32Z 2014-12-24T20:25:51Z Mitomycin C06681 27504 Mitomycin DB00305 true [H][C@]12CN3C4=C(C(=O)C(N)=C(C)C4=O)[C@@]([H])(COC(O)=N)[C@@]3(OC)[C@@]1([H])N2 C15H18N4O5 InChI=1S/C15H18N4O5/c1-5-9(16)12(21)8-6(4-24-14(17)22)15(23-2)13-7(18-13)3-19(15)10(8)11(5)20/h6-7,13,18H,3-4,16H2,1-2H3,(H2,17,22)/t6-,7+,13+,15-/m1/s1 InChIKey=NWIBSHFKIJFRCO-WUDYKRTCSA-N 334.3272 334.127719706 Exogenous Solid -0.4 HMDB14450 CHEMBL105 5544 <p>Leslie Jimenez, Zheng Wang, &#8220;Synthesis of mitomycin and its analogs.&#8221; U.S. Patent US5523411, issued June, 1972.</p>