2815 Procyclidine Procyclidine is only found in individuals that have used or taken this drug. It is a muscarinic antagonist that crosses the blood-brain barrier and is used in the treatment of drug-induced extrapyramidal disorders and in parkinsonism. The mechanism of action is unknown. It is thought that Procyclidine acts by blocking central cholinergic receptors, and thus balancing cholinergic and dopaminergic activity in the basal ganglia. Many of its effects are due to its pharmacologic similarities with atropine. Procyclidine exerts an antispasmodic effect on smooth muscle, and may produce mydriasis and reduction in salivation. 77-37-2 4919 C19H29NO 287.224920 White powder. 86°C Moderately soluble in water, ~ 30 mg/ml Oral The mechanism of action is unknown. It is thought that Procyclidine acts by blocking central cholinergic receptors, and thus balancing cholinergic and dopaminergic activity in the basal ganglia. Many of its effects are due to its pharmacologic similarities with atropine. Procyclidine exerts an antispasmodic effect on smooth muscle, and may produce mydriasis and reduction in salivation. LD₅₀=60 mg/kg (IV in mice) No indication of carcinogenicity to humans (not listed by IARC). For the treatment of all forms of Parkinson's Disease, as well as control of extrapyramidal reactions induced by antipsychotic agents. LD₅₀=60 mg/kg (IV in mice) 2009-07-21T20:26:46Z 2014-12-24T20:25:51Z Procyclidine C07378 8448 Procyclidine DB00387 true OC(CCN1CCCC1)(C1CCCCC1)C1=CC=CC=C1 C19H29NO InChI=1/C19H29NO/c21-19(17-9-3-1-4-10-17,18-11-5-2-6-12-18)13-16-20-14-7-8-15-20/h1,3-4,9-10,18,21H,2,5-8,11-16H2 InChIKey=WYDUSKDSKCASEF-UHFFFAOYNA-N 287.4397 287.224914555 Exogenous Solid 4.2 HMDB14531 CHEMBL86715 4750