2855 Triflupromazine Triflupromazine is only found in individuals that have used or taken this drug. It is a phenothiazine used as an antipsychotic agent and as an antiemetic. Triflupromazine binds to the dopamine D1 and dopamine D2 receptors and inhibits their activity. The mechanism of the anti-emetic effect is due predominantly to blockage of the dopamine D2 neurotransmitter receptors in the chemoreceptor trigger zone (CTZ) and vomiting centre. Triflupromazine blocks the neurotransmitter dopamine and the vagus nerve in the gastrointestinal tract. Triflupromazine also binds the muscarinic acetylcholine receptors (M1 and M2) and the tryptamine D receptors (5HT_2B). 146-54-3 5568 C18H19F3N2S 352.122100 White powder. 176°C at 7.00E-01 mm Hg 1.80e-03 g/L Absorption may be erratic and peak plasma concentrations show large interindividual differences. Triflupromazine binds to the dopamine D1 and dopamine D2 receptors and inhibits their activity. The mechanism of the anti-emetic effect is due predominantly to blockage of the dopamine D2 neurotransmitter receptors in the chemoreceptor trigger zone (CTZ) and vomiting centre. Triflupromazine blocks the neurotransmitter dopamine and the vagus nerve in the gastrointestinal tract. Triflupromazine also binds the muscarinic acetylcholine receptors (M1 and M2) and the tryptamine D receptors (5HT_2B). Hepatic. No indication of carcinogenicity to humans (not listed by IARC). Used mainly in the management of psychoses. Also used to control nausea and vomiting. Symptoms of overdose include agitation, coma, convulsions, difficulty breathing, difficulty swallowing, dry mouth, extreme sleepiness, fever, intestinal blockage, irregular heart rate, low blood pressure, and restlessness. 2009-07-21T20:27:04Z 2014-12-24T20:25:51Z Triflupromazine 9711 Triflupromazine DB00508 true CN(C)CCCN1C2=CC=CC=C2SC2=C1C=C(C=C2)C(F)(F)F C18H19F3N2S InChI=1S/C18H19F3N2S/c1-22(2)10-5-11-23-14-6-3-4-7-16(14)24-17-9-8-13(12-15(17)23)18(19,20)21/h3-4,6-9,12H,5,10-11H2,1-2H3 InChIKey=XSCGXQMFQXDFCW-UHFFFAOYSA-N 352.417 352.122103923 Exogenous Solid 5.54 HMDB14650 CHEMBL570 5367