2882 Fluphenazine Fluphenazine is only found in individuals that have used or taken this drug. It is a phenothiazine used in the treatment of psychoses. Its properties and uses are generally similar to those of chlorpromazine. [PubChem]Fluphenazine blocks postsynaptic mesolimbic dopaminergic D1 and D2 receptors in the brain; depresses the release of hypothalamic and hypophyseal hormones and is believed to depress the reticular activating system thus affecting basal metabolism, body temperature, wakefulness, vasomotor tone, and emesis. 69-23-8 3372 C22H26F3N3OS 437.174870 White powder. 224-226°C (Salt) 268-274°C at 5.00E-01 mm Hg 31.1 mg/L (at 37°C) Oral, Intramuscular Fluphenazine blocks postsynaptic mesolimbic dopaminergic D1 and D2 receptors in the brain; depresses the release of hypothalamic and hypophyseal hormones and is believed to depress the reticular activating system thus affecting basal metabolism, body temperature, wakefulness, vasomotor tone, and emesis. No indication of carcinogenicity to humans (not listed by IARC). For management of manifestations of psychotic disorders. 2009-07-21T20:27:16Z 2014-12-24T20:25:52Z Fluphenazine C07010 5123 Fluphenazine DB00623 true OCCN1CCN(CCCN2C3=CC=CC=C3SC3=C2C=C(C=C3)C(F)(F)F)CC1 C22H26F3N3OS InChI=1S/C22H26F3N3OS/c23-22(24,25)17-6-7-21-19(16-17)28(18-4-1-2-5-20(18)30-21)9-3-8-26-10-12-27(13-11-26)14-15-29/h1-2,4-7,16,29H,3,8-15H2 InChIKey=PLDUPXSUYLZYBN-UHFFFAOYSA-N 437.522 437.174867774 Exogenous Solid 4.36 HMDB14761 CHEMBL726 3255 <p>Ullyot, G.E.; U.S. Patent 3,058,979; October 16, 1962; assigned to Smith Kline &amp; French<br /> Laboratories.</p>