2912 Trimipramine Trimipramine is only found in individuals that have used or taken this drug. It is a tricyclic antidepressant similar to imipramine, but with more antihistaminic and sedative properties. [PubChem]Trimipramine's mechanism of action differs from other tricyclic antidepressants. Trimipramine acts by decreasing the reuptake of norepinephrine and serotonin (5-HT). 739-71-9 5584 C20H26N2 294.209600 White powder. 45°C Slightly soluble Oral. Rapid absorption Trimipramine's mechanism of action differs from other tricyclic antidepressants. Trimipramine acts by decreasing the reuptake of norepinephrine and serotonin (5-HT). Hepatic Half Life: 11-18 hrs No indication of carcinogenicity to humans (not listed by IARC). For the treatment of depression and depression accompanied by anxiety, agitation or sleep disturbance Side effects include agitation, coma, confusion, convulsions, dilated pupils, disturbed concentration, drowsiness, hallucinations, high fever, irregular heart rate, low body temperature, muscle rigidity, overactive reflexes, severely low blood pressure, stupor, vomiting Obtain an ECG and immediately initiate cardiac monitoring. Protect the patient's airway, establish an intravenous line and initiate gastric decontamination. A minimum of six hours of observation with cardiac monitoring and observation for signs of CNS or respiratory depression, hypotension, cardiac dysrhythmias and/or conduction blocks, and seizures is necessary. If signs of toxicity occur at any time during this period, extended monitoring is required. (L1712) 2009-07-21T20:27:30Z 2014-12-24T20:25:52Z Trimipramine C14029 9738 Trimipramine DB00726 true CC(CN(C)C)CN1C2=CC=CC=C2CCC2=CC=CC=C12 C20H26N2 InChI=1/C20H26N2/c1-16(14-21(2)3)15-22-19-10-6-4-8-17(19)12-13-18-9-5-7-11-20(18)22/h4-11,16H,12-15H2,1-3H3 InChIKey=ZSCDBOWYZJWBIY-UHFFFAOYNA-N 294.4338 294.209598842 Exogenous Solid 4.2 HMDB14864 CHEMBL644 5382