2916 Meclizine Meclizine is only found in individuals that have used or taken this drug. It is a histamine H1 antagonist used in the treatment of motion sickness, vertigo, and nausea during pregnancy and radiation sickness. [PubChem]Along with its actions as an antagonist at H₁-receptors, meclizine also possesses anticholinergic, central nervous system depressant, and local anesthetic effects. Meclizine depresses labyrinth excitability and vestibular stimulation and may affect the medullary chemoreceptor trigger zone. 569-65-3 4034 C25H27ClN2 390.186280 White powder. 217-224°C 0.1gm/100ml Oral. Well absorbed Along with its actions as an antagonist at H₁-receptors, meclizine also possesses anticholinergic, central nervous system depressant, and local anesthetic effects. Meclizine depresses labyrinth excitability and vestibular stimulation and may affect the medullary chemoreceptor trigger zone. Hepatic Half Life: 6 hours LD50: 1600 mg/kg (oral) (A701) LD50: 659 mg/kg (i.p.) (A701) No indication of carcinogenicity to humans (not listed by IARC). For the prevention and treatment of nausea, vomiting, or dizziness associated with motion sickness. Symptoms of overdose include drowsiness and anticholinergic effects. 2009-07-21T20:27:31Z 2014-12-24T20:25:52Z Meclizine C07116 569632 Meclizine DB00737 true CC1=CC(CN2CCN(CC2)C(C2=CC=CC=C2)C2=CC=C(Cl)C=C2)=CC=C1 C25H27ClN2 InChI=1/C25H27ClN2/c1-20-6-5-7-21(18-20)19-27-14-16-28(17-15-27)25(22-8-3-2-4-9-22)23-10-12-24(26)13-11-23/h2-13,18,25H,14-17,19H2,1H3 InChIKey=OCJYIGYOJCODJL-UHFFFAOYNA-N 390.948 390.186276581 Exogenous Solid 5.8 HMDB14875 CHEMBL1623 3894 <p>U.S. Patent 2,709,169.</p>