2924 Isoflurane Isoflurane is only found in individuals that have used or taken this drug. It is a stable, non-explosive inhalation anesthetic, relatively free from significant side effects. [PubChem]Isoflurane induces a reduction in junctional conductance by decreasing gap junction channel opening times and increasing gap junction channel closing times. Isoflurane also activates calcium dependent ATPase in the sarcoplasmic reticulum by increasing the fluidity of the lipid membrane. Also appears to bind the D subunit of ATP synthase and NADH dehydogenase. Isoflurane also binds to the GABA receptor, the large conductance Ca²⁺ activated potassium channel, the glutamate receptor and the glycine receptor. 26675-46-7 3763 C3H2ClF5O 183.971430 48-48.5°C 48.5°C 4470 mg/L (at 37°C) Inhalation Isoflurane induces a reduction in junctional conductance by decreasing gap junction channel opening times and increasing gap junction channel closing times. Isoflurane also activates calcium dependent ATPase in the sarcoplasmic reticulum by increasing the fluidity of the lipid membrane. Also appears to bind the D subunit of ATP synthase and NADH dehydogenase. Isoflurane also binds to the GABA receptor, the large conductance Ca²⁺ activated potassium channel, the glutamate receptor and the glycine receptor. Minimal LC50=15300 ppm/3 hrs (inhalation by rat) No indication of carcinogenicity to humans (not listed by IARC). For induction and maintenance of general anesthesia. May lead to cardiac arrhythmias and death (Rarely). In susceptible individuals, Isoflurane anesthesia may trigger a skeletal muscle hypermetabolic state leading to high oxygen demand and the clinical syndrome known as malignant hyperthermia. The syndrome includes nonspecific features such as muscle rigidity, tachycardia, tachypnea, cyanosis, arrhythmias, and unstable blood pressure.(L1471) The predicted effects of acute overexposure by inhalation of Isoflurane, USP include headache, dizziness or (in extreme cases) unconsciousness. (L1471) Stop drug administration, establish a clear airway, and initiate assisted or controlled ventilation with pure oxygen. (L1712) 2009-07-21T20:27:35Z 2014-12-24T20:25:52Z Isoflurane C07518 6015 Isoflurane DB00753 true FC(F)OC(Cl)C(F)(F)F C3H2ClF5O InChI=1/C3H2ClF5O/c4-1(3(7,8)9)10-2(5)6/h1-2H InChIKey=PIWKPBJCKXDKJR-UHFFFAOYNA-N 184.492 183.971433418 Exogenous Liquid 2.06 HMDB14891 CHEMBL1256 3631 <p>Leonid A. Rozov, Fernando Quiroz, Gerald G. Vernice, &#8220;Preparation of isoflurane.&#8221; U.S. Patent US5416244, issued March, 1973.</p>