2938 Proparacaine Proparacaine is only found in individuals that have used or taken this drug. It is a topical anesthetic drug of the amino ester group. It is available as its hydrochloride salt in ophthalmic solutions at a concentration of 0.5%. [Wikipedia]The exact mechanism whereby proparacaine and other local anesthetics influence the permeability of the cell membrane is unknown; however, several studies indicate that local anesthetics may limit sodium ion permeability through the lipid layer of the nerve cell membrane. Proparacaine may alter epithelial sodium channels through interaction with channel protein residues. This limitation prevents the fundamental change necessary for the generation of the action potential. 499-67-2 4935 C16H26N2O3 294.194340 White powder. 182-183.3°C 1.39e+00 g/L Topical (eye drop). The exact mechanism whereby proparacaine and other local anesthetics influence the permeability of the cell membrane is unknown; however, several studies indicate that local anesthetics may limit sodium ion permeability through the lipid layer of the nerve cell membrane. Proparacaine may alter epithelial sodium channels through interaction with channel protein residues. This limitation prevents the fundamental change necessary for the generation of the action potential. Plasma No indication of carcinogenicity to humans (not listed by IARC). Used as an ophthalmic anesthetic (as eye drops) to reduce pain and discomfort during procedures involving the eye. [Wikipedia] Dizziness or drowsiness; increased sweating; irregular heartbeat; muscle twitching or trembling; nausea or vomiting; shortness of breath or troubled breathing; unusual excitement, nervousness, or restlessness; unusual tiredness or weakness. Burning, stinging, redness, or other irritation of eye. (L1482) 2009-07-21T20:27:41Z 2014-12-24T20:25:53Z Proparacaine C07383 309007 Proparacaine DB00807 true CCCOC1=C(N)C=C(C=C1)C(=O)OCCN(CC)CC C16H26N2O3 InChI=1S/C16H26N2O3/c1-4-10-20-15-8-7-13(12-14(15)17)16(19)21-11-9-18(5-2)6-3/h7-8,12H,4-6,9-11,17H2,1-3H3 InChIKey=KCLANYCVBBTKTO-UHFFFAOYSA-N 294.3892 294.194342708 Exogenous Solid 2.5 HMDB14945 CHEMBL1196 4766