2975 T3D2933 Mesoridazine Mesoridazine is only found in individuals that have used or taken this drug. It is a phenothiazine antipsychotic with effects similar to chlorpromazine. [PubChem]Based upon animal studies, mesoridazine, as with other phenothiazines, acts indirectly on reticular formation, whereby neuronal activity into reticular formation is reduced without affecting its intrinsic ability to activate the cerebral cortex. In addition, the phenothiazines exhibit at least part of their activities through depression of hypothalamic centers. Neurochemically, the phenothiazines are thought to exert their effects by a central adrenergic blocking action. 5588-33-0 4078 C21H26N2OS2 386.148660 White powder. 7.67e-02 g/L Oral; Intramuscular injection. Well absorbed from the gastrointestinal tract. Based upon animal studies, mesoridazine, as with other phenothiazines, acts indirectly on reticular formation, whereby neuronal activity into reticular formation is reduced without affecting its intrinsic ability to activate the cerebral cortex. In addition, the phenothiazines exhibit at least part of their activities through depression of hypothalamic centers. Neurochemically, the phenothiazines are thought to exert their effects by a central adrenergic blocking action. Half Life: 24 to 48 hours Oral LD<sub>50</sub> is 560 &plusmn; 62.5 mg/kg and 644 &plusmn; 48 mg/kg in mouse and rat, respectively. No indication of carcinogenicity to humans (not listed by IARC). Used in the treatment of schizophrenia, organic brain disorders, alcoholism and psychoneuroses. Symptoms of overdose may include emesis, muscle tremors, decreased food intake and death associated with aspiration of oral-gastric contents into the respiratory system. 2009-07-21T20:27:59Z 2014-12-24T20:25:53Z Mesoridazine C07143 6780 Mesoridazine DB00933 true CN1CCCCC1CCN1C2=CC=CC=C2SC2=C1C=C(C=C2)S(C)=O C21H26N2OS2 InChI=1/C21H26N2OS2/c1-22-13-6-5-7-16(22)12-14-23-18-8-3-4-9-20(18)25-21-11-10-17(26(2)24)15-19(21)23/h3-4,8-11,15-16H,5-7,12-14H2,1-2H3 InChIKey=SLVMESMUVMCQIY-UHFFFAOYNA-N 386.574 386.148654844 Exogenous Solid 3.9 HMDB15068 CHEMBL1088 3936 <p><a href="http://www.drugsyn.org/Mesoridazine.htm">DrugSyn.org</a></p>