3021 T3D2979 Pilocarpine Pilocarpine is only found in individuals that have used or taken this drug. It is a slowly hydrolyzed muscarinic agonist with no nicotinic effects. Pilocarpine is used as a miotic and in the treatment of glaucoma. [PubChem]Pilocarpine is a cholinergic parasympathomimetic agent. It increase secretion by the exocrine glands, and produces contraction of the iris sphincter muscle and ciliary muscle (when given topically to the eyes) by mainly stimulating muscarinic receptors. 54-71-7 5910 C11H16N2O2 208.121180 White powder. 204-205°C 1E+006 mg/L (at 25°C) Oral ; eye contact. There was a decrease in the rate of absorption of pilocarpine from SALAGEN Tablets when taken with a high fat meal by 12 healthy male volunteers Pilocarpine is a cholinergic parasympathomimetic agent. It increase secretion by the exocrine glands, and produces contraction of the iris sphincter muscle and ciliary muscle (when given topically to the eyes) by mainly stimulating muscarinic receptors. Possibly occurs at the neuronal synapses and in the plasma Half Life: 0.76 hours No indication of carcinogenicity to humans (not listed by IARC). For the treatment of radiation-induced dry mouth (xerostomia) and symptoms of dry mouth in patients with Sj&ouml;grens syndrome. Overdosage should be treated with atropine titration (0. 5 mg to 1. 0 mg given subcutaneously or intravenously) and supportive measures to maintain respiration and circulation. Epinephrine (0. 3 mg to 1. 0 mg, subcutaneously or intramuscularly) may also be of value in the presence of severe cardiovascular depression or bronchoconstriction. (L1712) 2009-07-21T20:28:20Z 2014-12-24T20:25:54Z Pilocarpine C07474 39462 Pilocarpine DB01085 9PL true [H][C@]1(CC2=CN=CN2C)COC(=O)[C@@]1([H])CC C11H16N2O2 InChI=1S/C11H16N2O2/c1-3-10-8(6-15-11(10)14)4-9-5-12-7-13(9)2/h5,7-8,10H,3-4,6H2,1-2H3/t8-,10-/m0/s1 InChIKey=QCHFTSOMWOSFHM-WPRPVWTQSA-N 208.2569 208.121177766 Exogenous Solid 1.1 HMDB15217 CHEMBL611494 5699 <p>Gerhard R. Reuther, &#8220;Process for the preparation of pilocarpine from in vitro cultures of pilocarpus.&#8221; U.S. Patent US5059531, issued June, 1987.</p>