3032 Phenacemide Phenacemide is only found in individuals that have used or taken this drug. It is used to control certain seizures in the treatment of epilepsy. This medicine acts on the central nervous system (CNS) to reduce the number and severity of seizures.Phenacemide binds to and blocks neuronal sodium channels or voltage sensitive calcium channels. This blocks or suppresses neuronal depolarization and hypersynchronization. Hypersynchronization is what often causes seizures. 63-98-9 4753 C9H10N2O2 178.074230 White powder. 215°C 10.2 g/L Almost completely absorbed. Phenacemide binds to and blocks neuronal sodium channels or voltage sensitive calcium channels. This blocks or suppresses neuronal depolarization and hypersynchronization. Hypersynchronization is what often causes seizures. Metabolized in the liver by hepatic microsomal enzymes, where it is inactivated by p-hydroxylation. Half Life: 22-25 hours. LD50: 987 mg/kg (Oral, Mouse) (A308) LD50: 2500 mg/kg (Oral, Rabbit) (A308) LD50: 1600 mg/kg (Oral, Rat) (A308) No indication of carcinogenicity to humans (not listed by IARC). Used to control certain seizures in the treatment of epilepsy. May cause a potentially dangerous rash that may develop into Stevens Johnson syndrome, an extremely rare but potentially fatal skin disease. 2009-07-21T20:28:25Z 2014-12-24T20:25:55Z Phenacemide C07428 183000 Phenacemide DB01121 true OC(=N)N=C(O)CC1=CC=CC=C1 C9H10N2O2 InChI=1S/C9H10N2O2/c10-9(13)11-8(12)6-7-4-2-1-3-5-7/h1-5H,6H2,(H3,10,11,12,13) InChIKey=XPFRXWCVYUEORT-UHFFFAOYSA-N 178.1879 178.074227574 Exogenous Solid 0.87 HMDB15253 CHEMBL918 4589