3047 Orphenadrine Orphenadrine is only found in individuals that have used or taken this drug. It is a muscarinic antagonist used to treat drug-induced parkinsonism and to relieve pain from muscle spasm. [PubChem] Orphenadrine binds and inhibits both histamine H1 receptors and NMDA receptors. It restores the motor disturbances induced by neuroleptics, in particular the hyperkinesia. The dopamine deficiency in the striatum increases the stimulating effects of the cholinergic system. This stimulation is counteracted by the anticholinergic effect of orphenadrine. It may have a relaxing effect on skeletal muscle spasms and it has a mood elevating effect. 83-98-7 4601 C18H23NO 269.177960 < 25°C 195°C at 1.20E+01 mm Hg Sparingly soluble in water Orphenadrine is almost completely absorbed in the gastrointestinal tract. Orphenadrine binds and inhibits both histamine H1 receptors and NMDA receptors. It restores the motor disturbances induced by neuroleptics, in particular the hyperkinesia. The dopamine deficiency in the striatum increases the stimulating effects of the cholinergic system. This stimulation is counteracted by the anticholinergic effect of orphenadrine. It may have a relaxing effect on skeletal muscle spasms and it has a mood elevating effect. Biotransformation occurs mainly in the liver. Pharmacologically active metabolites are N-demethyl orphenadrine and N,N-didemethyl orphenadrine. Half Life: 13-20 hours LD50: 100 mg/kg (Oral, Mouse) (A308) LD50: 255 mg/kg (Oral, Rat) (A308) No indication of carcinogenicity to humans (not listed by IARC). Indicated for the treatment of Parkinson's disease. Treatment for orphenadrine overdose is evacuation of stomach contents (when necessary), charcoal at repeated doses, intensive monitoring, and appropriate supportive treatment of any emergent anticholinergic effects. (L1712) 2009-07-21T20:28:31Z 2014-12-24T20:25:55Z Orphenadrine C07935 7789 Orphenadrine DB01173 true CN(C)CCOC(C1=CC=CC=C1)C1=CC=CC=C1C C18H23NO InChI=1/C18H23NO/c1-15-9-7-8-12-17(15)18(20-14-13-19(2)3)16-10-5-4-6-11-16/h4-12,18H,13-14H2,1-3H3 InChIKey=QVYRGXJJSLMXQH-UHFFFAOYNA-N 269.3813 269.177964363 Exogenous Liquid 3.77 HMDB15304 CHEMBL900 4440