3055 T3D3013 Desflurane Desflurane is a highly fluorinated methyl ethyl ether used for maintenance of general anaesthesia. Volatile agents such as desflurane may activate GABA channels and hyperpolarize cell membranes. In addition, they may inhibit certain calcium channels and therefore prevent release of neurotransmitters and inhibit glutamate channels. Volatile anesthetics easily partition into cellular membranes and could expand the volume of the cell membrane and subsequently distort channels necessary for sodium ion flux and the development of action potentials necessary for synaptic transmission. Desflurane preconditions human myocardium against ischemia through activation of mitochondrial K(ATP) channels, adenosine A1 receptor, and alpha and beta adrenoceptors. 57041-67-5 42113 C3H2F6O 168.000980 23.5°C Negligible Rapidly absorbed into the circulation via the lungs following inhalation. Desflurane induces a reduction in junctional conductance by decreasing gap junction channel opening times and increasing gap junction channel closing times. Desflurane also activates calcium dependent ATPase in the sarcoplasmic reticulum by increasing the fluidity of the lipid membrane. It also appears to bind the D subunit of ATP synthase and NADH dehydogenase. Desflurane also binds to and agonizes the GABA receptor, the large conductance Ca<sup>2+</sup> activated potassium channel, the glycine receptors, and antagonizes the glutamate receptors. Minimally biotransformed in the liver in humans (approximately 0.02% of the quantity absorbed). LD50: 312.0 mg.kg-1 (i.v,swiss rate) (A698) No indication of carcinogenicity to humans (not listed by IARC). Used for maintenance of general anesthesia. Due to this airway irritability, Desflurane is infrequently used to induce anesthesia via inhalation techniques. [Wikipedia] It may cause tachycardia and airway irritability when administered at concentrations greater than 10 vol%. [Wikipedia] In the event of overdosage, or suspected overdosage, take the following actions: discontinue administration of Desflurane, maintain a patent airway, initiate assisted or controlled ventilation with oxygen, and maintain adequate cardiovascular function. (L1712) 2009-07-21T20:28:35Z 2014-12-24T20:25:55Z Desflurane C07519 4445 Desflurane DB01189 true FC(F)OC(F)C(F)(F)F C3H2F6O InChI=1/C3H2F6O/c4-1(3(7,8)9)10-2(5)6/h1-2H InChIKey=DPYMFVXJLLWWEU-UHFFFAOYNA-N 168.0378 168.000983916 Exogenous Gas 1.9 HMDB15320 CHEMBL1200733 38403 <p>Leonid A. Rozov, Chialang Huang, Gerald G. Vernice, &#8220;Synthesis of desflurane.&#8221; U.S. Patent US5205914, issued June, 1991.</p>