3062 Mitoxantrone Mitoxantrone is only found in individuals that have used or taken this drug. It is an anthracenedione-derived antineoplastic agent. Mitoxantrone, a DNA-reactive agent that intercalates into deoxyribonucleic acid (DNA) through hydrogen bonding, causes crosslinks and strand breaks. Mitoxantrone also interferes with ribonucleic acid (RNA) and is a potent inhibitor of topoisomerase II, an enzyme responsible for uncoiling and repairing damaged DNA. It has a cytocidal effect on both proliferating and nonproliferating cultured human cells, suggesting lack of cell cycle phase specificity. 65271-80-9 4212 C22H28N4O6 444.200890 7.34e-01 g/L Intravenous injection. Poorly absorbed following oral administration. Mitoxantrone, a DNA-reactive agent that intercalates into deoxyribonucleic acid (DNA) through hydrogen bonding, causes crosslinks and strand breaks. Mitoxantrone also interferes with ribonucleic acid (RNA) and is a potent inhibitor of topoisomerase II, an enzyme responsible for uncoiling and repairing damaged DNA. It has a cytocidal effect on both proliferating and nonproliferating cultured human cells, suggesting lack of cell cycle phase specificity. Hepatic Half Life: 75 hours 2B, possibly carcinogenic to humans. (L135) For the treatment of secondary (chronic) progressive, progressive relapsing, or worsening relapsing-remitting multiple sclerosis. Mitoxantrone is an Anthracenedione (not an anthracycline) antineoplastic agent. Cardiomyopathy is a particularly concerning effect as it is irreversible. [Wikipedia] Severe leukopenia with infection. 2009-07-21T20:28:38Z 2014-12-24T20:25:55Z Mitoxantrone C11195 50729 Mitoxantrone DB01204 MIX true OCCNCCNC1=C2C(=O)C3=C(O)C=CC(O)=C3C(=O)C2=C(NCCNCCO)C=C1 C22H28N4O6 InChI=1S/C22H28N4O6/c27-11-9-23-5-7-25-13-1-2-14(26-8-6-24-10-12-28)18-17(13)21(31)19-15(29)3-4-16(30)20(19)22(18)32/h1-4,23-30H,5-12H2 InChIKey=KKZJGLLVHKMTCM-UHFFFAOYSA-N 444.4809 444.200884648 Exogenous Liquid -3.1 HMDB15335 CHEMBL58 4067 <p><a href="http://www.drugsyn.org/Mitoxantrone.htm">DrugSyn.org</a></p>