3145 Fumarin Fumarin is an anticoagulant and rodenticide derived from coumarin. (L1252) 117-52-2 8335 C17H14O5 298.084120 White powder. 124°C Oral (ingestion) (L1817) ; dermal (L1817) Fumarin inhibits the enzyme Vitamin K epoxide reductase. This enzyme is needed for the reconstitution of the vitamin K in its cycle from vitamin K-epoxide, and so fumarin steadily decreases the level of active vitamin K in the blood. Vitamin K is required for the synthesis of important substances including prothrombin, which is involved in blood clotting. This disruption becomes increasingly severe until the blood effectively loses any ability to clot. In addition, fumarin increases permeability of blood capillaries. The blood plasma and blood itself begins to leak from the blood vessels, causing internal bleeding leading to shock, loss of consciousness, and eventually death. (L1257) LD50: 14.7 mg/kg (Oral, Mouse) (A584) No indication of carcinogenicity to humans (not listed by IARC). Fumarin is a rodenticide. (L1252) Fumarin is an anticoagulant and causes internal bleeding, leading to shock, loss of consciousness, and eventually death. (L1257) Fumarin initially causes dehydration before progressing to bleeding complications. (L1257) The primary antidote to fumarin poisoning is immediate administration of vitamin K1 (initially slow intravenous injections of 10-25 mg repeated all 3-6 hours until normalisation of the prothrombin time; then 10 mg orally four times daily as a "maintenance dose"). It is an extremely effective antidote, provided the poisoning is caught before too much damage has been done to the victim's circulatory system. At high doses fumarin can affect the body for many months, and the antidote must be administered regularly for a long period of time. (L1257) 2009-07-23T18:26:18Z 2014-12-24T20:25:59Z Fumarin true CC(=O)CC(C1=CC=CO1)C1=C(O)OC2=CC=CC=C2C1=O C17H14O5 InChI=1S/C17H14O5/c1-10(18)9-12(13-7-4-8-21-13)15-16(19)11-5-2-3-6-14(11)22-17(15)20/h2-8,12,20H,9H2,1H3 InChIKey=VGVYRHYDNGFIGF-UHFFFAOYSA-N 298.2901 298.084123558 Exogenous Solid 8032