3534 Cephalosporin Ceftibuten is a third-generation cephalosporin antibiotic. It is an orally-administered agent. Cefalexin is used to treat acute bacterial exacerbations of chronic bronchitis (ABECB), acute bacterial otitis media, pharyngitis, and tonsilitis. 97519-39-6 5282242 C15H14N4O6S2 White powder. Rapidly absorbed following oral administration. Ceftibuten exerts its bactericidal action by binding to essential target proteins of the bacterial cell wall. This binding leads to inhibition of cell-wall synthesis. A study with radiolabeled ceftibuten administered to 6 healthy adult male volunteers demonstrated that cis-ceftibuten is the predominant component in both plasma and urine. About 10% of ceftibuten is converted to the trans-isomer is approximately 1/8 as antimicrobially potent as the cis-isomer. Route of Elimination: Ceftibuten is excreted in the urine; 95% of the administered radioactivity was recovered either in urine or feces. No indication of carcinogenicity to humans (not listed by IARC). Used to treat acute bacterial exacerbations of chronic bronchitis (ABECB), acute bacterial otitis media, pharyngitis, and tonsilitis. It is also indicated for pneumonia, infections of the urinary tract, enteritis and gastroenteritis. [Wikipedia] Overdosage of cephalosporins can cause cerebral irritation leading to convulsions. 2009-07-30T17:58:46Z 2014-12-24T20:26:07Z Ceftibuten C08117 3510 Cephalosporin DB01415 true [H]\C(CC(O)=O)=C(\C(O)=N[C@]1([H])C(=O)N2C(=CCS[C@]12[H])C(O)=O)C1=CSC(=N)N1 C15H14N4O6S2 InChI=1S/C15H14N4O6S2/c16-15-17-7(5-27-15)6(1-2-9(20)21)11(22)18-10-12(23)19-8(14(24)25)3-4-26-13(10)19/h1,3,5,10,13H,2,4H2,(H2,16,17)(H,18,22)(H,20,21)(H,24,25)/b6-1-/t10-,13-/m1/s1 InChIKey=UNJFKXSSGBWRBZ-BJCIPQKHSA-N 410.425 410.03547558 Exogenous Solid CHEMBL1605 4445418