3537 Ciprofloxacin Ciprofloxacin is only found in individuals that have used or taken this drug. It is a broad-spectrum antimicrobial carboxyfluoroquinoline. The bactericidal action of ciprofloxacin results from inhibition of the enzymes topoisomerase II (DNA gyrase) and topoisomerase IV, which are required for bacterial DNA replication, transcription, repair, strand supercoiling repair, and recombination. 85721-33-1 2764 C17H18FN3O3 331.133220 White powder. 255-257°C 3E+004 mg/L (at 20°C) Eye contact; parenteral (intravenous injection); oral. Rapidly and well absorbed from the gastrointestinal tract after oral administration. The absolute bioavailability is approximately 70% with no substantial loss by first pass metabolism. The bactericidal action of ciprofloxacin results from inhibition of the enzymes topoisomerase II (DNA gyrase) and topoisomerase IV, which are required for bacterial DNA replication, transcription, repair, strand supercoiling repair, and recombination. Hepatic. Four metabolites have been identified in human urine which together account for approximately 15% of an oral dose. The metabolites have antimicrobial activity, but are less active than unchanged ciprofloxacin. Route of Elimination: Approximately 40 to 50% of an orally administered dose is excreted in the urine as unchanged drug. Half Life: 4 hours No indication of carcinogenicity to humans (not listed by IARC). For the treatment of the following infections caused by susceptible organisms: urinary tract infections, acute uncomplicated cystitis, chronic bacterial prostatitis, lower respiratory tract infections, acute sinusitis, skin and skin structure infections, bone and joint infections, complicated intra-abdominal infections (used in combination with metronidazole), infectious diarrhea, typhoid fever (enteric fever), uncomplicated cervical and urethral gonorrhea, and inhalational anthrax (post-exposure). Inflammation of the skin (exfoliative dermatitis) The major adverse effect seen with use of is gastrointestinal irritation, common with many antibiotics. 2009-07-30T17:58:47Z 2014-12-24T20:26:07Z Ciprofloxacin C05349 100241 Ciprofloxacin DB00537 CPF true OC(=O)C1=CN(C2CC2)C2=CC(N3CCNCC3)=C(F)C=C2C1=O C17H18FN3O3 InChI=1S/C17H18FN3O3/c18-13-7-11-14(8-15(13)20-5-3-19-4-6-20)21(10-1-2-10)9-12(16(11)22)17(23)24/h7-10,19H,1-6H2,(H,23,24) InChIKey=MYSWGUAQZAJSOK-UHFFFAOYSA-N 331.3415 331.133219662 Exogenous Solid 0.28 HMDB14677 CHEMBL8 2662 <p><a href="http://www.drugsyn.org/Ciprofloxacin.htm">DrugSyn.org</a></p>