3683 Sodium laureth sulfate Sodium laureth sulfate is a detergent and surfactant found in many personal care products (soaps, shampoos, toothpaste etc.). It is an inexpensive and very effective foaming agent made by mixing sulfuric acid, monododecyl ester, and sodium salt. Sodium laureth sulfate may cause eye or skin irritation. (L1899) 9004-82-4 23665884 C14H29NaO5S White powder. 0.187 mg/mL at 25°C Oral (A2880) ; inhalation (A2880) ; dermal (L1889) While sodium laureth sulfate itself is not toxic, it is a nitrosating agent. Nitrosating agents may decompose and/or react to cause nitrosamine contamination. Nitrosamines are produced from secondary amines and amides in the presence of nitrite ions and are believed to be carcinogenic. Once in the body, nitrosamines are activated by cytochrome P-450 enzymes. They are then believed to induce their carcinogenic effects by forming DNA adducts at the N- and O-atoms. Sodium laureth sulfate may also be contaminated with low levels of 1,4-dioxane, another believed carcinogen. (L1889, L1890, A2878, A2879, A2880, L1899) Nitrosamines can enter the body via ingestion, inhalation, or dermal contact. Once in the body, nitrosamines are metabolized by cytochrome P-450 enzymes, which essentially activates them into carcinogens. (A2878, A2879) Not listed by IARC. Certain nitrosamines are classified by IARC as either probably or possibly carcinogenic to humans (Groups 2A and 2B, respectively). (L135) Sodium laureth sulfate is a detergent and surfactant found in many personal care products (soaps, shampoos, toothpaste etc.). (L1899) Sodium laureth sulfate may cause skin and eye irritation, as well as increase the frequency of canker sores when used in toothpaste. It may also react to produce nitrosamines or contain low levels of 1,4-dioxane, both of which are believed to be carcinogenic. (L1890, L1899) Sodium laureth sulfate may cause skin and eye irritation, as well as increase the frequency of canker sores when used in toothpaste. (L1899) 2009-11-28T02:36:32Z 2014-12-24T20:26:15Z http://en.wikipedia.org/wiki/Sodium_laureth_sulfate true Cytochrome P450 2A1 (P11711) Cytochrome P450 2A6 (P11509) Cytochrome P450 2E1 (P05181) NAD(P)H dehydrogenase [quinone] 1 (P15559) (A2878, A2879) [Na+].CCCCCCCCCCCCOCCOS([O-])(=O)=O C14H29NaO5S InChI=1S/C14H30O5S.Na/c1-2-3-4-5-6-7-8-9-10-11-12-18-13-14-19-20(15,16)17;/h2-14H2,1H3,(H,15,16,17);/q;+1/p-1 InChIKey=ASEFUFIKYOCPIJ-UHFFFAOYSA-M 332.432 332.163339403 Exogenous Solid 23146