3946 Niclosamide Niclosamide is used for the treatment of most tapeworm infections. Helminths (worms) are multicellular organisms that infect very large numbers of humans and cause a broad range of diseases. Over 1 billion people are infected with intestinal nematodes, and many millions are infected with filarial nematodes, flukes, and tapeworms. They are an even greater problem in domestic animals. 50-65-7 4477 C13H8Cl2N2O4 White powder. 230°C 1.6 mg/L (at 20°C) Niclosamide appears to be minimally absorbed from the gastrointestinal tract - neither the drug nor its metabolites have been recovered from the blood or urine. Niclosamide works by killing tapeworms on contact. Adult worms (but not ova) are rapidly killed, presumably due to uncoupling of oxidative phosphorylation or stimulation of ATPase activity. The killed worms are then passed in the stool or sometimes destroyed in the intestine. Niclosamide may work as a molluscicide by binding to and damaging DNA. No indication of carcinogenicity to humans (not listed by IARC). For the treatment of tapeworm and intestinal fluke infections: Taenia saginata (Beef Tapeworm), Taenia solium (Pork Tapeworm), Diphyllobothrium latum (Fish Tapeworm), Fasciolopsis buski (large intestinal fluke). Niclosamide is also used as a molluscicide in the control of schistosomiasis. 2013-04-25T07:56:53Z 2014-12-24T20:26:34Z Niclosamide 478218 DB06803 true OC(=NC1=C(Cl)C=C(C=C1)N(=O)=O)C1=C(O)C=CC(Cl)=C1 C13H8Cl2N2O4 InChI=1S/C13H8Cl2N2O4/c14-7-1-4-12(18)9(5-7)13(19)16-11-3-2-8(17(20)21)6-10(11)15/h1-6,18H,(H,16,19) InChIKey=RJMUSRYZPJIFPJ-UHFFFAOYSA-N 327.12 325.986112168 Exogenous Solid HMDB15679 CHEMBL1448 4322 <p><a href="http://www.drugsyn.org/Niclosamide.htm">DrugSyn.org</a></p>