4744 Dacarbazine Dacarbazine is only found in individuals that have used or taken this drug. It is an antineoplastic agent. It has significant activity against melanomas. The mechanism of action is not known, but appears to exert cytotoxic effects via its action as an alkylating agent. Other theories include DNA synthesis inhibition by its action as a purine analog, and interaction with SH groups. Dacarbazine is not cell cycle-phase specific. 4342-03-4 C6H10N6O White powder. 205°C 4220 mg/L Erratic, slow and incomplete. The mechanism of action is not known, but appears to exert cytotoxic effects via its action as an alkylating agent. Other theories include DNA synthesis inhibition by its action as a purine analog, and interaction with SH groups. Dacarbazine is not cell cycle-phase specific. Hepatic. Route of Elimination: Dacarbazine is subject to renal tubular secretion rather than glomerular filtration. In man, dacarbazine is extensively degraded. Besides unchanged dacarbazine, 5-aminoimidazole -4 carboxamide (AIC) is a major metabolite of dacarbazine excreted in the urine. Half Life: 5 hours LD₅₀=350mg/kg (orally in mice) 2B, possibly carcinogenic to humans. (L135) Dacarbazine is used in the treatment of various cancers, among them malignant melanoma, Hodgkin lymphoma, sarcoma, and islet cell carcinoma of the pancreas. As of mid-2006, dacarbazine is commonly used as a single agent in the treatment of metastatic melanoma, and as part of the ABVD chemotherapy regimen to treat Hodgkin lymphoma, and in the MAID regimen for sarcoma. (Wikipedia) 2014-09-11T02:05:03Z 2014-12-24T20:26:55Z http://en.wikipedia.org/wiki/Dacarbazine 4305 DB00851 true CN(C)N=NC1=C(N=CN1)C(N)=O C6H10N6O InChI=1S/C6H10N6O/c1-12(2)11-10-6-4(5(7)13)8-3-9-6/h3H,1-2H3,(H2,7,13)(H,8,9) InChIKey=FDKXTQMXEQVLRF-UHFFFAOYSA-N 182.1832 182.091608972 Exogenous Solid -0.24 HMDB14989 CHEMBL476 10437816