4807 Nitrofural A topical anti-infective agent effective against gram-negative and gram-positive bacteria. It is used for superficial wounds, burns, ulcers, and skin infections. Nitrofurazone has also been administered orally in the treatment of trypanosomiasis. 59-87-0 5447130 C6H6N4O4 White powder. 238 dec°C 210 mg/L (at 25°C) Well absorbed. The exact mechanism of action is unknown. Nitrofurazone inhibits several bacterial enzymes, especially those involved in the aerobic and anaerobic degradation of glucose and pyruvate. This activity is believed also to affect pyruvate dehydrogenase, citrate synthetase, malate dehydrogenase, glutathione reductase, and pyruvate decarboxylase. Nitrofurans, including nitrofural, undergo metabolic reduction at the nitro group to generate reactive species which can covalently bind to cellular macromolecules. Half Life: 5 hours Rat LD₅₀ = 590 mg/kg 3, not classifiable as to its carcinogenicity to humans. (L135) For the treatement of bacterial skin infections including pyodermas, infected dermatoses and infections of cuts, wounds, burns and ulcers due to susceptible organisms. Allergic contact dermatitis is the most frequently reported adverse effect, occurring in approximately 1 % of patients treated. 2014-09-11T05:14:52Z 2014-12-24T20:26:56Z Nitrofurazone C08042 170239 DB00336 NFZ true [H]\C(=N/NC(O)=N)C1=CC=C(O1)N(=O)=O C6H6N4O4 InChI=1S/C6H6N4O4/c7-6(11)9-8-3-4-1-2-5(14-4)10(12)13/h1-3H,(H3,7,9,11)/b8-3+ InChIKey=IAIWVQXQOWNYOU-FPYGCLRLSA-N 198.1362 198.0389047 Exogenous Solid 0.23 HMDB14480 CHEMBL869 4566720