4868 Masoprocol A potent lipoxygenase inhibitor that interferes with arachidonic acid metabolism. The compound also inhibits formyltetrahydrofolate synthetase, carboxylesterase, and cyclooxygenase to a lesser extent. It also serves as an antioxidant in fats and oils. 500-38-9 71398 C18H22O4 White powder. 185.5°C Less than 1%-2% is absorbed through the skin over a 4-day period following application. Although the exact mechanism of action is not known, studies have shown that masoprocol is a potent 5-lipoxygenase inhibitor and has antiproliferative activity against keratinocytes in tissue culture, but the relationship between this activity and its effectiveness in actinic keratoses is unknown. Masoprocol also inhibits prostaglandins but the significance of this action is not yet known. No indication of carcinogenicity to humans (not listed by IARC). Used for the treatment of actinic keratoses (precancerous skin growths that can become malignant if left untreated). Symptoms of overdose or allergic reaction include bluish coloration of skin, dizziness, severe, or feeling faint, wheezing or trouble in breathing. 2014-09-11T05:17:43Z 2014-12-24T20:26:57Z Masoprocol C10719 CPD-7661 D009637 DB00179 true [H][C@](C)(CC1=CC(O)=C(O)C=C1)[C@]([H])(C)CC1=CC(O)=C(O)C=C1 C18H22O4 InChI=1/C18H22O4/c1-11(7-13-3-5-15(19)17(21)9-13)12(2)8-14-4-6-16(20)18(22)10-14/h3-6,9-12,19-22H,7-8H2,1-2H3/t11-,12+ InChIKey=HCZKYJDFEPMADG-TXEJJXNPNA-N 302.3649 302.151809192 Exogenous Solid 5.8 HMDB12270 CHEMBL52 64490