NameKinesin-like protein KIF2A
Synonyms
  • hK2
  • KIF2
  • Kinesin-2
  • KNS2
Gene NameKIF2A
OrganismHuman
Amino acid sequence
>lcl|BSEQ0009158|Kinesin-like protein KIF2A
MATANFGKIQIGIYVEIKRSDGRIHQAMVTSLNEDNESVTVEWIENGDTKGKEIDLESIF
SLNPDLVPDEEIEPSPETPPPPASSAKVNKIVKNRRTVASIKNDPPSRDNRVVGSARARP
SQFPEQSSSAQQNGSVSDISPVQAAKKEFGPPSRRKSNCVKEVEKLQEKREKRRLQQQEL
REKRAQDVDATNPNYEIMCMIRDFRGSLDYRPLTTADPIDEHRICVCVRKRPLNKKETQM
KDLDVITIPSKDVVMVHEPKQKVDLTRYLENQTFRFDYAFDDSAPNEMVYRFTARPLVET
IFERGMATCFAYGQTGSGKTHTMGGDFSGKNQDCSKGIYALAARDVFLMLKKPNYKKLEL
QVYATFFEIYSGKVFDLLNRKTKLRVLEDGKQQVQVVGLQEREVKCVEDVLKLIDIGNSC
RTSGQTSANAHSSRSHAVFQIILRRKGKLHGKFSLIDLAGNERGADTSSADRQTRLEGAE
INKSLLALKECIRALGRNKPHTPFRASKLTQVLRDSFIGENSRTCMIATISPGMASCENT
LNTLRYANRVKELTVDPTAAGDVRPIMHHPPNQIDDLETQWGVGSSPQRDDLKLLCEQNE
EEVSPQLFTFHEAVSQMVEMEEQVVEDHRAVFQESIRWLEDEKALLEMTEEVDYDVDSYA
TQLEAILEQKIDILTELRDKVKSFRAALQEEEQASKQINPKRPRAL
Number of residues706
Molecular Weight79953.875
Theoretical pINot Available
GO Classification
Functions
  • ATPase activity
  • motor activity
  • microtubule motor activity
  • ATP binding
Processes
  • blood coagulation
  • mitotic spindle assembly
  • mitotic spindle organization
  • small GTPase mediated signal transduction
  • microtubule depolymerization
  • cell division
  • cell differentiation
  • nervous system development
  • antigen processing and presentation of exogenous peptide antigen via MHC class II
  • mitotic cell cycle
  • microtubule-based movement
Components
  • microtubule
  • spindle pole
  • kinesin complex
  • nucleus
  • cytosol
  • nucleolus
  • membrane
  • centrosome
  • sperm principal piece
General FunctionMotor activity
Specific FunctionPlus end-directed microtubule-dependent motor required for normal brain development. May regulate microtubule dynamics during axonal growth. Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate. Required for normal spindle dynamics during mitosis. Promotes spindle turnover. Implicated in formation of bipolar mitotic spindles. Has microtubule depolymerization activity.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein IDNot Available
UniProtKB IDO00139
UniProtKB Entry NameKIF2A_HUMAN
Cellular LocationCytoplasm
Gene sequence
>lcl|BSEQ0013645|Kinesin-like protein KIF2A (KIF2A)
ATGGCAACGGCCAACTTCGGCAAGATCCAGATCGGGATTTACGTGGAGATCAAGCGCAGC
GATGGCCGAATACATCAAGCAATGGTAACATCTTTAAATGAAGATAATGAAAGTGTAACT
GTTGAATGGATAGAAAATGGAGATACAAAAGGCAAAGAGATTGACCTGGAGAGCATCTTT
TCACTTAACCCTGACCTTGTTCCTGATGAAGAAATTGAACCCAGTCCAGAAACACCTCCA
CCTCCAGCATCCTCAGCCAAAGTAAACAAAATTGTAAAGAATCGACGGACTGTAGCTTCT
ATTAAGAATGACCCTCCTTCAAGAGATAATAGAGTGGTTGGTTCAGCACGTGCACGGCCC
AGTCAATTTCCTGAACAGTCTTCCTCTGCACAACAGAATGGTAGTGTTTCAGATATATCT
CCAGTTCAAGCTGCAAAAAAGGAATTTGGACCCCCTTCACGTAGAAAATCTAATTGTGTG
AAAGAAGTAGAAAAACTGCAAGAAAAACGAGAGAAAAGGAGATTGCAACAGCAAGAACTT
AGAGAAAAAAGAGCCCAGGACGTTGATGCTACAAACCCAAATTATGAAATTATGTGTATG
ATCAGAGACTTTAGAGGAAGTTTGGATTATAGACCATTAACAACAGCAGATCCTATTGAT
GAACATAGGATATGTGTGTGTGTAAGAAAACGACCACTCAATAAAAAAGAAACTCAAATG
AAAGATCTTGATGTAATCACAATTCCTAGTAAAGATGTTGTGATGGTACATGAACCAAAA
CAAAAAGTAGATTTAACAAGGTACCTAGAAAACCAAACATTTCGTTTTGATTATGCCTTT
GATGACTCAGCTCCTAATGAAATGGTTTACAGGTTTACTGCTAGACCACTAGTGGAAACT
ATATTTGAAAGGGGAATGGCTACATGCTTTGCTTATGGGCAGACTGGAAGTGGAAAAACT
CATACTATGGGTGGTGACTTTTCAGGAAAGAACCAAGATTGTTCTAAAGGAATTTATGCA
TTAGCAGCTCGAGATGTCTTTTTAATGCTAAAGAAGCCAAACTATAAGAAGCTAGAACTT
CAAGTATATGCAACCTTCTTTGAAATTTATAGTGGAAAGGTGTTTGACTTGCTAAACAGG
AAAACAAAATTAAGAGTTCTAGAAGATGGAAAACAGCAGGTTCAAGTGGTGGGATTACAG
GAACGGGAGGTCAAATGTGTTGAAGATGTACTGAAACTCATTGACATAGGCAACAGTTGC
AGAACATCCGGTCAAACATCTGCAAATGCACATTCATCTCGGAGCCATGCAGTGTTTCAG
ATTATTCTTAGAAGGAAAGGAAAACTACATGGCAAATTTTCTCTCATTGATTTGGCTGGA
AATGAAAGAGGAGCTGATACTTCCAGTGCGGACAGGCAAACTAGGCTTGAAGGTGCTGAA
ATTAATAAAAGCCTTTTAGCACTCAAGGAGTGCATCAGAGCCTTAGGTAGAAATAAACCT
CATACTCCTTTCCGTGCAAGTAAACTCACTCAGGTGTTAAGAGATTCTTTCATAGGTGAA
AACTCTCGTACCTGCATGATTGCCACAATCTCTCCAGGAATGGCATCCTGTGAAAATACT
CTTAATACATTAAGATATGCAAATAGAGTAAAGGAGTTTGGAATTAGTCCATCAGACATT
CCCTTCTCACAGGGTAGTGGCAGTCGCCCTGATCTCTCTCCTTCTTATGAATATGACGAC
TTTTCTCCTTCAGTTACCAGGGTCAAAGAATTGACTGTAGATCCAACTGCTGCTGGTGAT
GTTCGTCCAATAATGCACCATCCACCAAACCAGATTGATGACTTAGAGACACAGTGGGGT
GTGGGGAGTTCCCCTCAGAGAGATGATCTAAAACTTCTTTGTGAACAAAATGAAGAAGAA
GTCTCTCCACAGTTGTTTACTTTCCACGAAGCTGTTTCACAAATGGTAGAAATGGAAGAA
CAAGTTGTAGAAGATCACAGGGCAGTGTTCCAGGAATCTATTCGGTGGTTAGAAGATGAA
AAGGCCCTCTTAGAGATGACTGAAGAAGTAGATTATGATGTCGATTCATATGCTACACAA
CTTGAAGCTATTCTTGAGCAAAAAATAGACATTTTAACTGAACTGCGGGATAAAGTGAAA
TCTTTCCGTGCAGCTCTACAAGAGGAGGAACAAGCCAGCAAGCAAATCAACCCGAAGAGA
CCCCGTGCCCTTTAA
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:6318
Chromosome Location5
LocusNot Available
References
  1. Debernardi S, Fontanella E, De Gregorio L, Pierotti MA, Delia D: Identification of a novel human kinesin-related gene (HK2) by the cDNA differential display technique. Genomics. 1997 May 15;42(1):67-73. 9177777
  2. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. 14702039
  3. Bechtel S, Rosenfelder H, Duda A, Schmidt CP, Ernst U, Wellenreuther R, Mehrle A, Schuster C, Bahr A, Blocker H, Heubner D, Hoerlein A, Michel G, Wedler H, Kohrer K, Ottenwalder B, Poustka A, Wiemann S, Schupp I: The full-ORF clone resource of the German cDNA Consortium. BMC Genomics. 2007 Oct 31;8:399. 17974005
  4. Schmutz J, Martin J, Terry A, Couronne O, Grimwood J, Lowry S, Gordon LA, Scott D, Xie G, Huang W, Hellsten U, Tran-Gyamfi M, She X, Prabhakar S, Aerts A, Altherr M, Bajorek E, Black S, Branscomb E, Caoile C, Challacombe JF, Chan YM, Denys M, Detter JC, Escobar J, Flowers D, Fotopulos D, Glavina T, Gomez M, Gonzales E, Goodstein D, Grigoriev I, Groza M, Hammon N, Hawkins T, Haydu L, Israni S, Jett J, Kadner K, Kimball H, Kobayashi A, Lopez F, Lou Y, Martinez D, Medina C, Morgan J, Nandkeshwar R, Noonan JP, Pitluck S, Pollard M, Predki P, Priest J, Ramirez L, Retterer J, Rodriguez A, Rogers S, Salamov A, Salazar A, Thayer N, Tice H, Tsai M, Ustaszewska A, Vo N, Wheeler J, Wu K, Yang J, Dickson M, Cheng JF, Eichler EE, Olsen A, Pennacchio LA, Rokhsar DS, Richardson P, Lucas SM, Myers RM, Rubin EM: The DNA sequence and comparative analysis of human chromosome 5. Nature. 2004 Sep 16;431(7006):268-74. 15372022
  5. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. 15489334
  6. Zhu C, Zhao J, Bibikova M, Leverson JD, Bossy-Wetzel E, Fan JB, Abraham RT, Jiang W: Functional analysis of human microtubule-based motor proteins, the kinesins and dyneins, in mitosis/cytokinesis using RNA interference. Mol Biol Cell. 2005 Jul;16(7):3187-99. Epub 2005 Apr 20. 15843429
  7. Manning AL, Ganem NJ, Bakhoum SF, Wagenbach M, Wordeman L, Compton DA: The kinesin-13 proteins Kif2a, Kif2b, and Kif2c/MCAK have distinct roles during mitosis in human cells. Mol Biol Cell. 2007 Aug;18(8):2970-9. Epub 2007 May 30. 17538014
  8. Jang CY, Wong J, Coppinger JA, Seki A, Yates JR 3rd, Fang G: DDA3 recruits microtubule depolymerase Kif2a to spindle poles and controls spindle dynamics and mitotic chromosome movement. J Cell Biol. 2008 Apr 21;181(2):255-67. doi: 10.1083/jcb.200711032. Epub 2008 Apr 14. 18411309
  9. Jang CY, Coppinger JA, Seki A, Yates JR 3rd, Fang G: Plk1 and Aurora A regulate the depolymerase activity and the cellular localization of Kif2a. J Cell Sci. 2009 May 1;122(Pt 9):1334-41. doi: 10.1242/jcs.044321. Epub 2009 Apr 7. 19351716
  10. Mayya V, Lundgren DH, Hwang SI, Rezaul K, Wu L, Eng JK, Rodionov V, Han DK: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. Sci Signal. 2009 Aug 18;2(84):ra46. doi: 10.1126/scisignal.2000007. 19690332
  11. Burkard TR, Planyavsky M, Kaupe I, Breitwieser FP, Burckstummer T, Bennett KL, Superti-Furga G, Colinge J: Initial characterization of the human central proteome. BMC Syst Biol. 2011 Jan 26;5:17. doi: 10.1186/1752-0509-5-17. 21269460
  12. Poirier K, Lebrun N, Broix L, Tian G, Saillour Y, Boscheron C, Parrini E, Valence S, Pierre BS, Oger M, Lacombe D, Genevieve D, Fontana E, Darra F, Cances C, Barth M, Bonneau D, Bernadina BD, N'guyen S, Gitiaux C, Parent P, des Portes V, Pedespan JM, Legrez V, Castelnau-Ptakine L, Nitschke P, Hieu T, Masson C, Zelenika D, Andrieux A, Francis F, Guerrini R, Cowan NJ, Bahi-Buisson N, Chelly J: Mutations in TUBG1, DYNC1H1, KIF5C and KIF2A cause malformations of cortical development and microcephaly. Nat Genet. 2013 Jun;45(6):639-47. doi: 10.1038/ng.2613. Epub 2013 Apr 21. 23603762