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Displaying toxins 1 - 25 of 3673 in total
T3DB ID Name
CAS Number
Formula
Weight
StructureTypeMechanism of Toxicity
T3D0001Arsenic
7440-38-2
As
74.920 g/mol
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  • Arsenic Compound
  • Cigarette Toxin
  • Food Toxin
  • Household Toxin
  • Inorganic Compound
  • Metabolite
  • Metal
  • Metalloid
  • Natural Compound
  • Pesticide
  • Pollutant
Arsenic and its metabolites disrupt ATP production through several mechanisms. At the level of the citric acid cycle, arsenic inhibits pyruvate dehydrogenase and by co...more
Number of Targets: 46
T3D0002Lead
7439-92-1
Pb
207.200 g/mol
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  • Cigarette Toxin
  • Food Toxin
  • Household Toxin
  • Industrial/Workplace Toxin
  • Inorganic Compound
  • Lead Compound
  • Metabolite
  • Metal
  • Natural Compound
  • Pollutant
Lead mimics other biologically important metals, such as zinc, calcium, and iron, competing as cofactors for many of their respective enzymatic reactions. For example,...more
Number of Targets: 31
T3D0003Mercury
7439-97-6
Hg
200.590 g/mol
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  • Cosmetic Toxin
  • Food Toxin
  • Household Toxin
  • Industrial/Workplace Toxin
  • Inorganic Compound
  • Mercury Compound
  • Metabolite
  • Metal
  • Natural Compound
  • Pollutant
High-affinity binding of the divalent mercuric ion to thiol or sulfhydryl groups of proteins is believed to be the major mechanism for the activity of mercury. Through...more
Number of Targets: 53
T3D0004Vinyl chloride
75-01-4
C2H3Cl
62.498 g/mol
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  • Cigarette Toxin
  • Household Toxin
  • Industrial Precursor/Intermediate
  • Industrial/Workplace Toxin
  • Organic Compound
  • Organochloride
  • Pollutant
  • Synthetic Compound
Vinyl chloride poisoning exhibits many of the characteristics of autoimmune diseases. This is believed to be the result of a reactive vinyl chloride intermediate metab...more
Number of Targets: 43
T3D0006Benzene
71-43-2
C6H6
78.112 g/mol
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  • Aromatic Hydrocarbon
  • Cigarette Toxin
  • Food Toxin
  • Gasoline Additive/Component
  • Household Toxin
  • Industrial Precursor/Intermediate
  • Industrial/Workplace Toxin
  • Metabolite
  • Natural Compound
  • Organic Compound
  • Pesticide
  • Pollutant
  • Solvent
The toxic agents of benzene are its metabolites. Benzene is able increase its toxicity by inducing cytochrome P450 2E1, its main metabolic enzyme. Benzene's primary to...more
Number of Targets: 101
T3D0007Cadmium
7440-43-9
Cd
112.410 g/mol
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  • Cadmium Compound
  • Cigarette Toxin
  • Food Toxin
  • Household Toxin
  • Industrial/Workplace Toxin
  • Inorganic Compound
  • Metabolite
  • Metal
  • Natural Compound
  • Pollutant
Cadmium initially binds to metallothionein and is transported to the kidney. Toxic effects are observed once the concentration of cadmium exceeds that of available met...more
Number of Targets: 27
T3D0009Benzo[a]pyrene
50-32-8
C20H12
252.309 g/mol
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  • Aromatic Hydrocarbon
  • Cigarette Toxin
  • Food Toxin
  • Industrial By-product/Pollutant
  • Industrial/Workplace Toxin
  • Natural Compound
  • Organic Compound
  • Pollutant
  • Polycyclic Aromatic Hydrocarbon
The ability of PAH's to bind to blood proteins such as albumin allows them to be transported throughout the body. Many PAH's induce the expression of cytochrome P450 e...more
Number of Targets: 9
T3D0010Benzo[b]fluoranthene
205-99-2
C20H12
252.309 g/mol
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  • Aromatic Hydrocarbon
  • Cigarette Toxin
  • Food Toxin
  • Industrial By-product/Pollutant
  • Industrial/Workplace Toxin
  • Natural Compound
  • Organic Compound
  • Pollutant
  • Polycyclic Aromatic Hydrocarbon
The ability of PAH's to bind to blood proteins such as albumin allows them to be transported throughout the body. Many PAH's induce the expression of cytochrome P450 e...more
Number of Targets: 5
T3D0011Chloroform
67-66-3
CHCl3
119.378 g/mol
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  • Cigarette Toxin
  • Drug
  • Food Toxin
  • Household Toxin
  • Indicator and Reagent
  • Industrial/Workplace Toxin
  • Metabolite
  • Organic Compound
  • Organochloride
  • Pesticide
  • Pollutant
  • Solvent
  • Synthetic Compound
Chloroform and the reactive intermediates of chloroform metabolism, especially phosgene, bind covalently and irreversibly to cellular macromolecules and cause cellular...more
Number of Targets: 41
T3D0012Clofenotane
50-29-3
C14H9Cl5
354.486 g/mol
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  • Cigarette Toxin
  • Food Toxin
  • Metabolite
  • Organic Compound
  • Organochloride
  • Pesticide
  • Pollutant
  • Synthetic Compound
DDT toxicity occurs via at least four mechanisms, possibly all functioning simultaneously. DDT reduces potassium transport across the membrane. DDT inhibits the inacti...more
Number of Targets: 64
T3D0013Aroclor 1254
11097-69-1
C12H5Cl5
326.433 g/mol
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  • Aromatic Hydrocarbon
  • Coolant
  • Industrial/Workplace Toxin
  • Organic Compound
  • Organochloride
  • Plasticizer
  • Pollutant
  • Polychlorinated Biphenyl
  • Synthetic Compound
The mechanism of action varies with the specific PCB. Dioxin-like PCBs bind to the aryl hydrocarbon receptor, which disrupts cell function by altering the transcriptio...more
Number of Targets: 8
T3D0014Aroclor 1260
11096-82-5
C12H4Cl6
360.878 g/mol
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  • Aromatic Hydrocarbon
  • Coolant
  • Industrial/Workplace Toxin
  • Organic Compound
  • Organochloride
  • Plasticizer
  • Pollutant
  • Polychlorinated Biphenyl
  • Synthetic Compound
The mechanism of action varies with the specific PCB. Dioxin-like PCBs bind to the aryl hydrocarbon receptor, which disrupts cell function by altering the transcriptio...more
Number of Targets: 7
T3D0015Dibenzo[a,h]anthracene
53-70-3
C22H14
278.347 g/mol
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  • Aromatic Hydrocarbon
  • Cigarette Toxin
  • Food Toxin
  • Industrial By-product/Pollutant
  • Industrial/Workplace Toxin
  • Natural Compound
  • Organic Compound
  • Pollutant
  • Polycyclic Aromatic Hydrocarbon
The ability of PAH's to bind to blood proteins such as albumin allows them to be transported throughout the body. Many PAH's induce the expression of cytochrome P450 e...more
Number of Targets: 7
T3D0016Trichloroethylene
1979-01-06
C2HCl3
131.388 g/mol
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  • Anesthetic
  • Cigarette Toxin
  • Food Toxin
  • Household Toxin
  • Industrial/Workplace Toxin
  • Metabolite
  • Organic Compound
  • Organochloride
  • Pollutant
  • Solvent
  • Synthetic Compound
The toxic and carcinogenic effects of trichloroethylene are believed to be caused mainly by its metabolites, including trichloroacetic acid, dichloroacetic acid, and c...more
Number of Targets: 50
T3D0017Dieldrin
60-57-1
C12H8Cl6O
380.909 g/mol
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  • Ether
  • Organic Compound
  • Organochloride
  • Pesticide
  • Pollutant
  • Synthetic Compound
Dieldrin antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of ...more
Number of Targets: 46
T3D0018Hexavalent chromium
18540-29-9
Cr
51.996 g/mol
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  • Chromium Compound
  • Industrial/Workplace Toxin
  • Inorganic Compound
  • Metal
  • Natural Compound
  • Pollutant
Hexavalent chromium's carcinogenic effects are caused by its metabolites, pentavalent and trivalent chromium. The DNA damage may be caused by hydroxyl radicals produce...more
Number of Targets: 5
T3D0019White Phosphorus
12185-10-3
P4
123.895 g/mol
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  • Industrial/Workplace Toxin
  • Inorganic Compound
  • Non-Metal
  • Pollutant
  • Synthetic Compound
Exposure to white phosphorus has been shown to damage the rough endoplasmic reticulum and cause a disaggregation of polyribosomes. This damage results in impairment of...more
Number of Targets: 0
T3D0020Chlordane
57-74-9
C10H6Cl8
409.779 g/mol
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  • Organic Compound
  • Organochloride
  • Pesticide
  • Pollutant
  • Synthetic Compound
Chlordane is believed to bind irreversibly to DNA, leading to cell death or altered cellular function. It also affects transcription by antagonizing estrogen-related r...more
Number of Targets: 54
T3D0021P,P'-DDE
72-55-9
C14H8Cl4
318.025 g/mol
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  • Organic Compound
  • Organochloride
  • Pesticide
  • Pollutant
  • Synthetic Compound
DDE toxicity occurs via at least four mechanisms, possibly all functioning simultaneously. DDE reduces potassium transport across the membrane. DDE inhibits the inacti...more
Number of Targets: 60
T3D0022Hexachlorobutadiene
87-68-3
C4Cl6
260.761 g/mol
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  • Industrial/Workplace Toxin
  • Organic Compound
  • Organochloride
  • Pollutant
  • Solvent
  • Synthetic Compound
It is believed that intermediates produced by modification of the S- 1,1,2,3,4-pentachlorodienyl cysteine derivative metabolite by gamma-glutamyltransferase are respon...more
Number of Targets: 40
T3D0024Aldrin
309-00-2
C12H8Cl6
364.910 g/mol
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  • Ether
  • Organic Compound
  • Organochloride
  • Pesticide
  • Pollutant
  • Synthetic Compound
Aldrin antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of ch...more
Number of Targets: 41
T3D0025P,P'-DDD
72-54-8
C14H10Cl4
320.041 g/mol
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  • Organic Compound
  • Organochloride
  • Pesticide
  • Pollutant
  • Synthetic Compound
DDD toxicity occurs via at least four mechanisms, possibly all functioning simultaneously. DDD reduces potassium transport across the membrane. DDD inhibits the inacti...more
Number of Targets: 62
T3D0026Benzidine
92-87-5
C12H12N2
184.237 g/mol
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  • Amine
  • Aromatic Hydrocarbon
  • Industrial/Workplace Toxin
  • Metabolite
  • Organic Compound
  • Pollutant
  • Synthetic Compound
N-acetylated benzidine metabolites are believed to form adducts with nucleic acids. Carcinogenesis is initiated when they are activated by peroxidation by prostaglandi...more
Number of Targets: 13
T3D0027Aroclor 1248
12672-29-6
C12H6Cl4
291.988 g/mol
Thumb
  • Aromatic Hydrocarbon
  • Coolant
  • Industrial/Workplace Toxin
  • Organic Compound
  • Organochloride
  • Plasticizer
  • Pollutant
  • Polychlorinated Biphenyl
  • Synthetic Compound
The mechanism of action varies with the specific PCB. Dioxin-like PCBs bind to the aryl hydrocarbon receptor, which disrupts cell function by altering the transcriptio...more
Number of Targets: 7
T3D0028Cyanide
1957-12-05
CN
26.018 g/mol
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  • Cyanide Compound
  • Food Toxin
  • Industrial/Workplace Toxin
  • Metabolite
  • Natural Compound
  • Nitrile
  • Organic Compound
  • Pollutant
Organic nitriles decompose into cyanide ions both in vivo and in vitro. Consequently the primary mechanism of toxicity for organic nitriles is their production of toxi...more
Number of Targets: 42
Displaying toxins 1 - 25 of 3673 in total