Dual specificity mitogen-activated protein kinase kinase 7

NameDual specificity mitogen-activated protein kinase kinase 7
Synonyms
  • 2.7.12.2
  • c-Jun N-terminal kinase kinase 2
  • JNK kinase 2
  • JNK-activating kinase 2
  • JNKK 2
  • JNKK2
  • MAP kinase kinase 7
  • MAPK/ERK kinase 7
  • MEK 7
  • MEK7
  • MKK7
  • PRKMK7
  • SAPK kinase 4
  • SAPKK-4
  • SAPKK4
  • SKK4
  • Stress-activated protein kinase kinase 4
Gene NameMAP2K7
OrganismHuman
Amino acid sequence
>lcl|BSEQ0004335|Dual specificity mitogen-activated protein kinase kinase 7
MAASSLEQKLSRLEAKLKQENREARRRIDLNLDISPQRPRPTLQLPLANDGGSRSPSSES
SPQHPTPPARPRHMLGLPSTLFTPRSMESIEIDQKLQEIMKQTGYLTIGGQRYQAEINDL
ENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRILMDLDVVLKSHDCPYIV
QCFGTFITNTDVFIAMELMGTCAEKLKKRMQGPIPERILGKMTVAIVKALYYLKEKHGVI
HRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRSAGCAAYMAPERIDPPDPTKPDYD
IRADVWSLGISLVELATGQFPYKNCKTDFEVLTKVLQEEPPLLPGHMGFSGDFQSFVKDC
LTKDHRKRPKYNKLLEHSFIKRYETLEVDVASWFKDVMAKTESPRTSGVLSQPHLPFFR
Number of residues419
Molecular Weight47484.49
Theoretical pI9.62
GO Classification
Functions
  • protein kinase binding
  • protein phosphatase binding
  • ATP binding
  • protein serine/threonine kinase activity
  • MAP kinase kinase activity
  • magnesium ion binding
  • enzyme binding
  • protein tyrosine kinase activity
Processes
  • activation of JUN kinase activity
  • toll-like receptor 2 signaling pathway
  • Fc-epsilon receptor signaling pathway
  • toll-like receptor 3 signaling pathway
  • apoptotic process
  • toll-like receptor 4 signaling pathway
  • toll-like receptor 5 signaling pathway
  • JNK cascade
  • toll-like receptor 9 signaling pathway
  • response to osmotic stress
  • toll-like receptor signaling pathway
  • toll-like receptor TLR1
  • response to heat
  • signal transduction
  • toll-like receptor TLR6
  • response to UV
  • TRIF-dependent toll-like receptor signaling pathway
  • MyD88-dependent toll-like receptor signaling pathway
  • response to tumor necrosis factor
  • MyD88-independent toll-like receptor signaling pathway
  • positive regulation of telomerase activity
  • positive regulation of telomere capping
  • positive regulation of telomere maintenance via telomerase
  • stress-activated MAPK cascade
  • innate immune response
  • toll-like receptor 10 signaling pathway
Components
  • cytoplasm
  • nucleus
  • cytosol
General FunctionProtein tyrosine kinase activity
Specific FunctionDual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K4/MKK4, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4/MKK4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The monophosphorylation of JNKs on the Thr residue is sufficient to increase JNK activity indicating that MAP2K7/MKK7 is important to trigger JNK activity, while the additional phosphorylation of the Tyr residue by MAP2K4/MKK4 ensures optimal JNK activation. Has a specific role in JNK signal transduction pathway activated by proinflammatory cytokines. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID2318119
UniProtKB IDO14733
UniProtKB Entry NameMP2K7_HUMAN
Cellular LocationNucleus
Gene sequence
>lcl|BSEQ0011596|Dual specificity mitogen-activated protein kinase kinase 7 (MAP2K7)
ATGGCGGCGTCCTCCCTGGAACAGAAGCTGTCCCGCCTGGAAGCAAAGCTGAAGCAGGAG
AACCGGGAGGCCCGGCGGAGGATCGACCTCAACCTGGATATCAGCCCCCAGCGGCCCAGG
CCCATTATTGTGATCACTCTAAGCCCTGCTCCTGCCCCGTCCCAACGAGCAGCCCTGCAG
CTCCCGCTGGCCAACGATGGGGGCAGCCGCTCGCCATCCTCAGAGAGCTCCCCGCAGCAC
CCCACGCCCCCCGCCCGGCCCCGCCACATGCTGGGGCTCCCGTCAACCCTGTTCACACCC
CGCAGCATGGAGAGCATTGAGATTGACCAGAAGCTGCAGGAGATCATGAAGCAGACGGGC
TACCTGACCATCGGGGGCCAGCGCTACCAGGCAGAAATCAACGACCTGGAGAACTTGGGC
GAGATGGGCAGCGGCACCTGCGGCCAGGTGTGGAAGATGCGCTTCCGGAAGACCGGCCAC
GTCATTGCCGTTAAGCAAATGCGGCGCTCCGGGAACAAGGAGGAGAACAAGCGCATCCTC
ATGGACCTGGATGTGGTGCTGAAGAGCCACGACTGCCCCTACATCGTGCAGTGCTTTGGG
ACGTTCATCACCAACACGGACGTCTTCATCGCCATGGAGCTCATGGGCACCTGCGCTGAG
AAGCTCAAGAAGCGGATGCAGGGCCCCATCCCCGAGCGCATTCTGGGCAAGATGACAGTG
GCGATTGTGAAGGCGCTGTACTACCTGAAGGAGAAGCACGGTGTCATCCACCGCGACGTC
AAGCCCTCCAACATCCTGCTGGACGAGCGGGGCCAGATCAAGCTCTGCGACTTCGGCATC
AGCGGCCGCCTGGTGGACTCCAAAGCCAAGACGCGGAGCGCCGGCTGTGCCGCCTACATG
GCACCCGAGCGCATTGACCCCCCAGACCCCACCAAGCCGGACTATGACATCCGGGCCGAC
GTATGGAGCCTGGGCATCTCGTTGGTGGAGCTGGCAACAGGACAGTTTCCCTACAAGAAC
TGCAAGACGGACTTTGAGGTCCTCACCAAAGTCCTACAGGAAGAGCCCCCGCTTCTGCCC
GGACACATGGGCTTCTCGGGGGACTTCCAGTCCTTCGTCAAAGACTGCCTTACTAAAGAT
CACAGGAAGAGACCAAAGTATAATAAGCTACTTGAACACAGCTTCATCAAGCGCTACGAG
ACGCTGGAGGTGGACGTGGCGTCCTGGTTCAAGGATGTCATGGCGAAGACTGAGTCACCG
CGGACTAGCGGCGTCCTGAGCCAGCCCCACCTGCCCTTCTTCAGGTAG
GenBank Gene IDAF014401
GeneCard IDNot Available
GenAtlas IDMAP2K7
HGNC IDHGNC:6847
Chromosome Location19
Locus19p13.3-p13.2
References
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