NameKinesin-like protein KIF3B
Synonyms
  • HH0048
  • KIAA0359
  • Microtubule plus end-directed kinesin motor 3B
Gene NameKIF3B
OrganismHuman
Amino acid sequence
>lcl|BSEQ0009508|Kinesin-like protein KIF3B
MSKLKSSESVRVVVRCRPMNGKEKAASYDKVVDVDVKLGQVSVKNPKGTAHEMPKTFTFD
AVYDWNAKQFELYDETFRPLVDSVLQGFNGTIFAYGQTGTGKTYTMEGIRGDPEKRGVIP
NSFDHIFTHISRSQNQQYLVRASYLEIYQEEIRDLLSKDQTKRLELKERPDTGVYVKDLS
SFVTKSVKEIEHVMNVGNQNRSVGATNMNEHSSRSHAIFVITIECSEVGLDGENHIRVGK
LNLVDLAGSERQAKTGAQGERLKEATKINLSLSALGNVISALVDGKSTHIPYRDSKLTRL
LQDSLGGNAKTVMVANVGPASYNVEETLTTLRYANRAKNIKNKPRVNEDPKDALLREFQE
EIARLKAQLEKRSIGRRKRREKRREGGGSGGGGEEEEEEGEEGEEEGDDKDDYWREQQEK
LEIEKRAIVEDHSLVAEEKMRLLKEKEKKMEDLRREKDAAEMLGAKIKAMESKLLVGGKN
IVDHTNEQQKILEQKRQEIAEQKRREREIQQQMESRDEETLELKETYSSLQQEVDIKTKK
LKKLFSKLQAVKAEIHDLQEEHIKERQELEQTQNELTRELKLKHLIIENFIPLEEKSKIM
NRAFFDEEEDHWKLHPITRLENQQMMKRPVSAVGYKRPLSQHARMSMMIRPEARYRAENI
VLLELDMPSRTTRDYEGPAIAPKVQAALDAALQDEDEIQVDASSFESTANKKSKARPKSG
RKSGSSSSSSGTPASQLYPQSRGLVPK
Number of residues747
Molecular Weight85124.58
Theoretical pINot Available
GO Classification
Functions
  • microtubule motor activity
  • Rho GTPase binding
  • ATP binding
  • ATP-dependent microtubule motor activity, plus-end-directed
Processes
  • anterograde axon cargo transport
  • blood coagulation
  • mitotic spindle assembly
  • mitotic spindle organization
  • membrane organization
  • mitotic centrosome separation
  • antigen processing and presentation of exogenous peptide antigen via MHC class II
  • organelle organization
  • determination of left/right symmetry
  • positive regulation of cytokinesis
  • microtubule-based movement
  • plus-end-directed vesicle transport along microtubule
Components
  • microtubule cytoskeleton
  • microtubule
  • spindle
  • cytosol
  • extracellular exosome
  • plus-end kinesin complex
  • ciliary tip
  • kinesin II complex
  • intraciliary transport particle
  • primary cilium
  • centrosome
  • membrane
  • midbody
General FunctionRho gtpase binding
Specific FunctionInvolved in tethering the chromosomes to the spindle pole and in chromosome movement. Microtubule-based anterograde translocator for membranous organelles. Plus end-directed microtubule sliding activity in vitro (By similarity).
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein IDNot Available
UniProtKB IDO15066
UniProtKB Entry NameKIF3B_HUMAN
Cellular LocationCytoplasm
Gene sequence
>lcl|BSEQ0021705|Kinesin-like protein KIF3B (KIF3B)
ATGTCAAAGTTGAAAAGCTCAGAGTCAGTCAGGGTGGTGGTTCGCTGTCGGCCCATGAAT
GGCAAGGAAAAGGCTGCTTCGTATGACAAAGTGGTGGATGTGGATGTTAAGCTGGGGCAG
GTGTCTGTGAAGAACCCCAAAGGGACGGCCCATGAAATGCCCAAGACCTTCACCTTTGAT
GCCGTCTATGACTGGAATGCCAAGCAGTTTGAACTGTACGATGAGACGTTCCGACCACTT
GTTGACTCTGTCCTGCAAGGTTTCAATGGAACCATTTTTGCCTATGGACAAACTGGGACA
GGAAAAACCTACACCATGGAAGGAATCCGTGGTGACCCTGAAAAAAGAGGAGTCATTCCT
AACTCATTTGACCATATCTTCACCCACATCTCTCGATCCCAGAATCAACAATACCTGGTC
AGGGCTTCTTACTTAGAGATCTACCAGGAGGAGATCCGAGATTTGCTCTCAAAGGATCAG
ACCAAAAGGCTTGAGCTCAAAGAGAGGCCTGACACAGGAGTGTATGTGAAAGACCTGTCT
TCCTTTGTCACCAAGAGTGTGAAGGAGATAGAGCATGTGATGAATGTGGGGAACCAGAAC
CGTTCTGTCGGTGCTACCAACATGAACGAGCACAGCTCGCGTTCTCATGCAATTTTCGTT
ATCACTATTGAGTGCAGCGAGGTGGGCCTCGATGGTGAAAACCACATCCGTGTAGGAAAA
TTGAACCTTGTAGATCTTGCTGGCAGCGAACGGCAAGCCAAGACCGGCGCACAAGGGGAG
AGATTAAAAGAAGCTACCAAGATCAACCTCTCCCTTTCCGCTTTGGGTAATGTCATCTCT
GCTCTAGTGGACGGCAAAAGCACTCACATTCCATATCGGGACTCAAAGCTTACCAGGCTC
CTCCAAGATTCCCTTGGTGGCAATGCCAAGACTGTGATGGTGGCCAACGTGGGGCCTGCC
TCTTACAACGTAGAAGAGACTCTGACCACTCTGCGATATGCCAACCGTGCCAAAAACATT
AAGAACAAACCAAGGGTCAATGAGGACCCCAAGGATGCCCTCCTTCGAGAATTCCAGGAA
GAGATTGCTCGGCTCAAGGCCCAGCTGGAAAAACGGTCCATTGGTAGGAGGAAGAGGCGA
GAGAAGCGGAGGGAAGGTGGTGGCAGTGGTGGGGGTGGGGAAGAGGAGGAGGAGGAGGGA
GAAGAGGGTGAGGAGGAAGGGGATGATAAGGATGATTACTGGCGGGAACAGCAAGAAAAA
CTGGAGATTGAGAAGCGGGCCATTGTAGAGGATCACAGCTTGGTTGCAGAGGAGAAGATG
AGGCTGCTGAAGGAGAAAGAGAAAAAGATGGAGGACCTGCGGCGGGAGAAGGATGCTGCC
GAGATGCTGGGCGCCAAGATCAAGGCCATGGAGAGTAAGTTGCTTGTTGGAGGAAAAAAT
ATAGTAGATCATACGAATGAACAGCAGAAAATCCTGGAGCAGAAACGACAGGAAATTGCA
GAGCAGAAACGTCGAGAAAGAGAAATCCAGCAACAGATGGAAAGTCGAGATGAGGAGACC
TTGGAACTTAAAGAGACATACAGCTCATTGCAGCAAGAGGTGGACATCAAGACCAAAAAA
CTCAAAAAGCTCTTCTCCAAGCTTCAGGCAGTGAAGGCTGAGATCCATGACCTCCAAGAA
GAACACATCAAGGAGCGCCAAGAGCTAGAGCAGACTCAGAATGAGCTCACCAGGGAGCTG
AAACTCAAGCATCTTATTATAGAAAACTTTATCCCTCTGGAAGAAAAAAGTAAAATTATG
AATAGAGCCTTCTTTGATGAAGAGGAAGATCATTGGAAACTACATCCTATAACCAGACTG
GAGAACCAGCAGATGATGAAGCGGCCAGTCTCAGCCGTGGGATATAAGAGACCATTGAGC
CAGCACGCAAGAATGTCCATGATGATTCGTCCAGAGGCCCGATATAGGGCAGAAAACATT
GTGCTGTTAGAGCTGGACATGCCCAGCCGGACCACCAGAGACTATGAGGGTCCAGCCATT
GCCCCCAAGGTCCAGGCTGCATTGGATGCGGCTCTGCAGGATGAAGATGAGATACAGGTG
GATGCATCATCATTTGAAAGCACTGCAAATAAGAAATCCAAGGCCAGGCCTAAAAGTGGA
AGGAAGTCGGGATCCTCCTCCTCTTCCTCAGGAACCCCTGCATCTCAGCTTTATCCACAG
TCTCGGGGGCTGGTTCCAAAGTAA
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:6320
Chromosome Location20
LocusNot Available
References
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