NameUDP-glucose 6-dehydrogenase
Synonyms
  • 1.1.1.22
  • UDP-Glc dehydrogenase
Gene NameUGDH
OrganismHuman
Amino acid sequence
>lcl|BSEQ0001286|UDP-glucose 6-dehydrogenase
MFEIKKICCIGAGYVGGPTCSVIAHMCPEIRVTVVDVNESRINAWNSPTLPIYEPGLKEV
VESCRGKNLFFSTNIDDAIKEADLVFISVNTPTKTYGMGKGRAADLKYIEACARRIVQNS
NGYKIVTEKSTVPVRAAESIRRIFDANTKPNLNLQVLSNPEFLAEGTAIKDLKNPDRVLI
GGDETPEGQRAVQALCAVYEHWVPREKILTTNTWSSELSKLAANAFLAQRISSINSISAL
CEATGADVEEVATAIGMDQRIGNKFLKASVGFGGSCFQKDVLNLVYLCEALNLPEVARYW
QQVIDMNDYQRRRFASRIIDSLFNTVTDKKIAILGFAFKKDTGDTRESSSIYISKYLMDE
GAHLHIYDPKVPREQIVVDLSHPGVSEDDQVSRLVTISKDPYEACDGAHAVVICTEWDMF
KELDYERIHKKMLKPAFIFDGRRVLDGLHNELQTIGFQIETIGKKVSSKRIPYAPSGEIP
KFSLQDPPNKKPKV
Number of residues494
Molecular Weight55023.545
Theoretical pI7.13
GO Classification
Functions
  • UDP-glucose 6-dehydrogenase activity
  • NAD binding
  • electron carrier activity
Processes
  • xenobiotic metabolic process
  • glycosaminoglycan biosynthetic process
  • gastrulation with mouth forming second
  • cellular glucuronidation
  • UDP-glucuronate biosynthetic process
  • UDP-glucose metabolic process
  • small molecule metabolic process
  • carbohydrate metabolic process
Components
  • cytosol
  • extracellular exosome
  • nucleoplasm
General FunctionUdp-glucose 6-dehydrogenase activity
Specific FunctionInvolved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID3127127
UniProtKB IDO60701
UniProtKB Entry NameUGDH_HUMAN
Cellular LocationNot Available
Gene sequence
>lcl|BSEQ0018990|UDP-glucose 6-dehydrogenase (UGDH)
ATGTTTGAAATTAAGAAGATCTGTTGCATCGGTGCAGGCTATGTTGGAGGACCCACATGT
AGTGTCATTGCTCATATGTGTCCTGAAATCAGGGTAACGGTTGTTGATGTCAATGAATCA
AGAATCAATGCGTGGAATTCTCCTACACTTCCTATTTATGAGCCAGGACTAAAAGAAGTG
GTAGAATCCTGTCGAGGAAAAAATCTTTTTTTTTCTACCAATATTGATGATGCCATCAAA
GAAGCTGATCTTGTATTTATTTCTGTGCTGTCCAACCCTGAGTTTCTGGCAGAGGGAACA
GCCATCAAGGACCTAAAGAACCCAGACAGAGTACTGATTGGAGGGGATGAAACTCCAGAG
GGCCAGAGAGCTGTGCAGGCCCTGTGTGCTGTATATGAGCACTGGGTTCCCAGAGAAAAG
ATCCTCACCACTAATACTTGGTCTTCAGAGCTTTCCAAACTGGCAGCAAATGCTTTTCTT
GCCCAGAGAATAAGCAGCATTAACTCCATAAGTGCTCTGTGTGAAGCAACAGGAGCTGAT
GTAGAAGAGGTAGCAACAGCGATTGGAATGGACCAGAGAATTGGAAACAAGTTTCTAAAA
GCCAGTGTTGGGTTTGGTGGGAGCTGTTTCCAAAAGGATGTTCTGAATTTGGTTTATCTC
TGTGAGGCTCTGAATTTGCCAGAAGTAGCTCGTTATTGGCAGCAGGTCATAGACATGAAT
GACTACCAGAGGAGGAGGTTTGCTTCCCGGATCATAGATAGTCTGTTTAATACAGTAACT
GATAAGAAGATAGCTATTTTGGGATTTGCATTCAAAAAGGACACTGGTGATACAAGAGAA
TCTTCTAGTATATATATTAGCAAATATTTGATGGATGAAGGTGCACATCTACATATATAT
GATCCAAAAGTACCTAGGGAACAAATAGTTGTGGATCTTTCTCATCCAGGTGTTTCAGAG
GATGACCAAGTGTCCCGGCTCGTGACCATTTCCAAGGATCCATATGAAGCATGTGATGGT
GCCCATGCTGTTGTTATTTGCACTGAGTGGGACATGTTTAAGGAATTGGATTATGAACGC
ATTCATAAAAAAATGCTAAAGCCAGCCTTTATCTTCGATGGACGGCGTGTCCTGGATGGG
CTCCACAATGAACTACAAACCATTGGCTTCCAGATTGAAACAATTGGCAAAAAGGTGTCT
TCAAAGAGAATTCCATATGCTCCTTCTGGTGAAATTCCGAAGTTTAGTCTTCAAGATCCA
CCTAACAAGAAACCTAAAGTGTAG
GenBank Gene IDAF061016
GeneCard IDNot Available
GenAtlas IDUGDH
HGNC IDHGNC:12525
Chromosome Location4
Locus4p15.1
References
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