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Sodium channel subunit beta-2
Name | Sodium channel subunit beta-2 |
---|---|
Synonyms | Not Available |
Gene Name | SCN2B |
Organism | Human |
Amino acid sequence | >lcl|BSEQ0012528|Sodium channel subunit beta-2 MHRDAWLPRPAFSLTGLSLFFSLVPPGRSMEVTVPATLNVLNGSDARLPCTFNSCYTVNH KQFSLNWTYQECNNCSEEMFLQFRMKIINLKLERFQDRVEFSGNPSKYDVSVMLRNVQPE DEGIYNCYIMNPPDRHRGHGKIHLQVLMEEPPERDSTVAVIVGASVGGFLAVVILVLMVV KCVRRKKEQKLSTDDLKTEEEGKTDGEGNPDDGAK |
Number of residues | 215 |
Molecular Weight | 24325.69 |
Theoretical pI | 6.35 |
GO Classification | Functions
Processes
Components
|
General Function | Voltage-gated sodium channel activity involved in cardiac muscle cell action potential |
Specific Function | Crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. The subunit beta-2 causes an increase in the plasma membrane surface area and in its folding into microvilli. Interacts with TNR may play a crucial role in clustering and regulation of activity of sodium channels at nodes of Ranvier (By similarity). |
Pfam Domain Function |
|
Transmembrane Regions | 160-180 |
GenBank Protein ID | 3309111 |
UniProtKB ID | O60939 |
UniProtKB Entry Name | SCN2B_HUMAN |
Cellular Location | Membrane |
Gene sequence | >lcl|BSEQ0012529|Sodium channel subunit beta-2 (SCN2B) ATGCACAGAGATGCCTGGCTACCTCGCCCTGCCTTCAGCCTCACGGGGCTCAGTCTCTTT TTCTCTTTGGTGCCACCAGGACGGAGCATGGAGGTCACAGTACCTGCCACCCTCAACGTC CTCAATGGCTCTGACGCCCGCCTGCCCTGCACCTTCAACTCCTGCTACACAGTGAACCAC AAACAGTTCTCCCTGAACTGGACTTACCAGGAGTGCAACAACTGCTCTGAGGAGATGTTC CTCCAGTTCCGCATGAAGATCATTAACCTGAAGCTGGAGCGGTTTCAAGACCGCGTGGAG TTCTCAGGGAACCCCAGCAAGTACGATGTGTCGGTGATGCTGAGAAACGTGCAGCCGGAG GATGAGGGGATTTACAACTGCTACATCATGAACCCCCCTGACCGCCACCGTGGCCATGGC AAGATCCATCTGCAGGTCCTCATGGAAGAGCCCCCTGAGCGGGACTCCACGGTGGCCGTG ATTGTGGGTGCCTCCGTCGGGGGCTTCCTGGCTGTGGTCATCTTGGTGCTGATGGTGGTC AAGTGTGTGAGGAGAAAAAAAGAGCAGAAGCTGAGCACAGATGACCTGAAGACCGAGGAG GAGGGCAAGACGGACGGTGAAGGCAACCCGGATGATGGCGCCAAGTAG |
GenBank Gene ID | AF007783 |
GeneCard ID | Not Available |
GenAtlas ID | Not Available |
HGNC ID | HGNC:10589 |
Chromosome Location | 11 |
Locus | 11q23 |
References |
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