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NameEpididymal secretory glutathione peroxidase
Synonyms
  • 1.11.1.9
  • EGLP
  • Epididymis-specific glutathione peroxidase-like protein
  • Glutathione peroxidase 5
  • GPx-5
  • GSHPx-5
Gene NameGPX5
OrganismHuman
Amino acid sequence
>lcl|BSEQ0001636|Epididymal secretory glutathione peroxidase
MTTQLRVVHLLPLLLACFVQTSPKQEKMKMDCHKDEKGTIYDYEAIALNKNEYVSFKQYV
GKHILFVNVATYCGLTAQYPELNALQEELKPYGLVVLGFPCNQFGKQEPGDNKEILPGLK
YVRPGGGFVPSFQLFEKGDVNGEKEQKVFSFLKHSCPHPSEILGTFKSISWDPVKVHDIR
WNFEKFLVGPDGIPVMRWSHRATVSSVKTDILAYLKQFKTK
Number of residues221
Molecular Weight25202.14
Theoretical pI8.89
GO Classification
Functions
  • glutathione peroxidase activity
Processes
  • cellular response to oxidative stress
  • lipid metabolic process
Components
  • extracellular space
  • sperm plasma membrane
General FunctionGlutathione peroxidase activity
Specific FunctionProtects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione. May constitute a glutathione peroxidase-like protective system against peroxide damage in sperm membrane lipids.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID3288455
UniProtKB IDO75715
UniProtKB Entry NameGPX5_HUMAN
Cellular LocationSecreted
Gene sequence
>lcl|BSEQ0016218|Epididymal secretory glutathione peroxidase (GPX5)
ATGACTACACAGTTAAGGGTCGTCCATCTGCTTCCCCTTCTCCTAGCCTGCTTTGTGCAA
ACAAGTCCCAAGCAGGAGAAGATGAAGATGGATTGCCACAAAGACGAGAAAGGCACCATC
TATGACTATGAGGCCATCGCACTTAATAAGAATGAATATGTTTCCTTCAAGCAGTATGTG
GGCAAGCACATCCTCTTCGTCAACGTGGCCACCTACTGTGGTCTGACAGCGCAATATCCT
GAACTAAATGCACTCCAGGAGGAGCTGAAGCCCTATGGTCTAGTTGTGTTGGGCTTTCCC
TGCAACCAATTTGGAAAGCAAGAACCAGGAGATAACAAAGAGATTCTTCCTGGGCTCAAG
TATGTCCGTCCAGGGGGAGGATTTGTACCTAGTTTCCAGCTTTTTGAGAAAGGGGATGTG
AATGGTGAAAAAGAACAGAAAGTCTTCAGTTTCTTGAAGCACTCCTGTCCTCATCCCTCT
GAGATTTTGGGCACATTCAAATCTATATCCTGGGACCCTGTAAAGGTCCATGACATCCGT
TGGAACTTTGAAAAGTTCCTGGTGGGGCCTGATGGAATCCCTGTCATGCGCTGGTCCCAC
CGGGCTACGGTCAGCTCAGTCAAGACAGACATCCTGGCGTACTTGAAGCAATTCAAAACC
AAATAG
GenBank Gene IDAJ005277
GeneCard IDNot Available
GenAtlas IDGPX5
HGNC IDHGNC:4557
Chromosome Location6
Locus6p22.1
References
  1. Hall L, Williams K, Perry AC, Frayne J, Jury JA: The majority of human glutathione peroxidase type 5 (GPX5) transcripts are incorrectly spliced: implications for the role of GPX5 in the male reproductive tract. Biochem J. 1998 Jul 1;333 ( Pt 1):5-9. 9639555
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