NameCytochrome b
Synonyms
  • COB
  • Complex III subunit 3
  • Complex III subunit III
  • CYTB
  • Cytochrome b-c1 complex subunit 3
  • MTCYB
  • Ubiquinol-cytochrome-c reductase complex cytochrome b subunit
Gene NameMT-CYB
OrganismHuman
Amino acid sequence
>lcl|BSEQ0010658|Cytochrome b
MTPMRKTNPLMKLINHSFIDLPTPSNISAWWNFGSLLGACLILQITTGLFLAMHYSPDAS
TAFSSIAHITRDVNYGWIIRYLHANGASMFFICLFLHIGRGLYYGSFLYSETWNIGIILL
LATMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTDLVQWIWGGYSVDSPTLTRFFT
FHFILPFIIAALATLHLLFLHETGSNNPLGITSHSDKITFHPYYTIKDALGLLLFLLSLM
TLTLFSPDLLGDPDNYTLANPLNTPPHIKPEWYFLFAYTILRSVPNKLGGVLALLLSILI
LAMIPILHMSKQQSMMFRPLSQSLYWLLAADLLILTWIGGQPVSYPFTIIGQVASVLYFT
TILILMPTISLIENKMLKWA
Number of residues380
Molecular Weight42717.055
Theoretical pI8.22
GO Classification
Functions
  • metal ion binding
  • ubiquinol-cytochrome-c reductase activity
  • electron carrier activity
Processes
  • response to hypoxia
  • respiratory electron transport chain
  • response to calcium ion
  • response to toxic substance
  • response to ethanol
  • response to cadmium ion
  • response to copper ion
  • hydrogen ion transmembrane transport
  • response to mercury ion
  • response to drug
  • response to heat
  • organ regeneration
  • response to glucagon
  • hyperosmotic salinity response
  • mitochondrial electron transport, ubiquinol to cytochrome c
  • small molecule metabolic process
  • cellular metabolic process
  • response to cobalamin
  • response to hyperoxia
Components
  • mitochondrion
  • mitochondrial inner membrane
  • mitochondrial respiratory chain complex III
General FunctionUbiquinol-cytochrome-c reductase activity
Specific FunctionComponent of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.
Pfam Domain Function
Transmembrane Regions33-53 76-98 115-135 138-158 178-198 230-250 288-308 323-343 349-369
GenBank Protein ID13016
UniProtKB IDP00156
UniProtKB Entry NameCYB_HUMAN
Cellular LocationMitochondrion inner membrane
Gene sequence
>lcl|BSEQ0010659|Cytochrome b (MT-CYB)
ATGACCCCAATACGCAAAACTAACCCCCTAATAAAATTAATTAACCACTCATTCATCGAC
CTCCCCACCCCATCCAACATCTCCGCATGATGAAACTTCGGCTCACTCCTTGGCGCCTGC
CTGATCCTCCAAATCACCACAGGACTATTCCTAGCCATGCACTACTCACCAGACGCCTCA
ACCGCCTTTTCATCAATCGCCCACATCACTCGAGACGTAAATTATGGCTGAATCATCCGC
TACCTTCACGCCAATGGCGCCTCAATATTCTTTATCTGCCTCTTCCTACACATCGGGCGA
GGCCTATATTACGGATCATTTCTCTACTCAGAAACCTGAAACATCGGCATTATCCTCCTG
CTTGCAACTATAGCAACAGCCTTCATAGGCTATGTCCTCCCGTGAGGCCAAATATCATTC
TGAGGGGCCACAGTAATTACAAACTTACTATCCGCCATCCCATACATTGGGACAGACCTA
GTTCAATGAATCTGAGGAGGCTACTCAGTAGACAGTCCCACCCTCACACGATTCTTTACC
TTTCACTTCATCTTGCCCTTCATTATTGCAGCCCTAGCAACACTCCACCTCCTATTCTTG
CACGAAACGGGATCAAACAACCCCCTAGGAATCACCTCCCATTCCGATAAAATCACCTTC
CACCCTTACTACACAATCAAAGACGCCCTCGGCTTACTTCTCTTCCTTCTCTCCTTAATG
ACATTAACACTATTCTCACCAGACCTCCTAGGCGACCCAGACAATTATACCCTAGCCAAC
CCCTTAAACACCCCTCCCCACATCAAGCCCGAATGATATTTCCTATTCGCCTACACAATT
CTCCGATCCGTCCCTAACAAACTAGGAGGCGTCCTTGCCCTATTACTATCCATCCTCATC
CTAGCAATAATCCCCATCCTCCATATATCCAAACAACAAAGCATAATATTTCGCCCACTA
AGCCAATCACTTTATTGACTCCTAGCCGCAGACCTCCTCATTCTAACCTGAATCGGAGGA
CAACCAGTAAGCTACCCTTTTACCATCATTGGACAAGTAGCATCCGTACTATACTTCACA
ACAATCCTAATCCTAATACCAACTATCTCCCTAATTGAAAACAAAATACTCAAATGGGCC
T
GenBank Gene IDV00662
GeneCard IDNot Available
GenAtlas IDMT-CYB
HGNC IDHGNC:7427
Chromosome LocationNot Available
Locus-
References
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