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  • Lactose synthase B protein
  • Lysozyme-like protein 7
  • LYZL7
Gene NameLALBA
Amino acid sequence
Number of residues142
Molecular Weight16224.695
Theoretical pINot Available
GO Classification
  • lactose synthase activity
  • calcium ion binding
  • defense response to bacterium
  • lactose biosynthetic process
  • signal transduction
  • cell-cell signaling
  • small molecule metabolic process
  • carbohydrate metabolic process
  • apoptotic process
  • Golgi lumen
  • extracellular space
  • Golgi membrane
General FunctionLactose synthase activity
Specific FunctionRegulatory subunit of lactose synthase, changes the substrate specificity of galactosyltransferase in the mammary gland making glucose a good acceptor substrate for this enzyme. This enables LS to synthesize lactose, the major carbohydrate component of milk. In other tissues, galactosyltransferase transfers galactose onto the N-acetylglucosamine of the oligosaccharide chains in glycoproteins.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein IDNot Available
UniProtKB IDP00709
Cellular LocationSecreted
Gene sequence
>lcl|BSEQ0012505|Alpha-lactalbumin (LALBA)
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
Chromosome Location12
LocusNot Available
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  2. Hall L, Emery DC, Davies MS, Parker D, Craig RK: Organization and sequence of the human alpha-lactalbumin gene. Biochem J. 1987 Mar 15;242(3):735-42. 2954544
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  4. Findlay JB, Brew K: The complete amino-acid sequence of human -lactalbumin. Eur J Biochem. 1972 May;27(1):65-86. 5049057
  5. Maynard F: Identification of a new molecular form of human alpha-lactalbumin. J Dairy Res. 1992 Aug;59(3):425-9. 1401360
  6. Picariello G, Ferranti P, Mamone G, Roepstorff P, Addeo F: Identification of N-linked glycoproteins in human milk by hydrophilic interaction liquid chromatography and mass spectrometry. Proteomics. 2008 Sep;8(18):3833-47. doi: 10.1002/pmic.200701057. 18780401
  7. Acharya KR, Ren JS, Stuart DI, Phillips DC, Fenna RE: Crystal structure of human alpha-lactalbumin at 1.7 A resolution. J Mol Biol. 1991 Sep 20;221(2):571-81. 1920433
  8. Ren J, Stuart DI, Acharya KR: Alpha-lactalbumin possesses a distinct zinc binding site. J Biol Chem. 1993 Sep 15;268(26):19292-8. 8366079
  9. Chandra N, Brew K, Acharya KR: Structural evidence for the presence of a secondary calcium binding site in human alpha-lactalbumin. Biochemistry. 1998 Apr 7;37(14):4767-72. 9537992
  10. Harata K, Abe Y, Muraki M: Crystallographic evaluation of internal motion of human alpha-lactalbumin refined by full-matrix least-squares method. J Mol Biol. 1999 Mar 26;287(2):347-58. 10080897
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