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  • CES1
  • Metallothionein-2A
  • Metallothionein-II
  • MT-2
  • MT-II
  • MT2
Gene NameMT2A
Amino acid sequence
Number of residues61
Molecular Weight6042.05
Theoretical pINot Available
GO Classification
  • drug binding
  • zinc ion binding
  • interferon-gamma-mediated signaling pathway
  • negative regulation of growth
  • cellular response to interleukin-3
  • cellular response to zinc ion
  • cellular copper ion homeostasis
  • cellular response to erythropoietin
  • cytokine-mediated signaling pathway
  • cellular response to drug
  • cytoplasm
  • nucleus
  • cytosol
  • perinuclear region of cytoplasm
General FunctionZinc ion binding
Specific FunctionMetallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein IDNot Available
UniProtKB IDP02795
UniProtKB Entry NameMT2_HUMAN
Cellular LocationNot Available
Gene sequence
>lcl|BSEQ0020798|Metallothionein-2 (MT2A)
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
Chromosome Location16
LocusNot Available
  1. Kissling MM, Kagi HR: Primary structure of human hepatic metallothionein. FEBS Lett. 1977 Oct 15;82(2):247-50. 913597
  2. Karin M, Richards RI: Human metallothionein genes--primary structure of the metallothionein-II gene and a related processed gene. Nature. 1982 Oct 28;299(5886):797-802. 7133118
  3. Karin M, Richards RI: Human metallothionein genes: molecular cloning and sequence analysis of the mRNA. Nucleic Acids Res. 1982 May 25;10(10):3165-73. 6896577
  4. Duguid JR, Bohmont CW, Liu NG, Tourtellotte WW: Changes in brain gene expression shared by scrapie and Alzheimer disease. Proc Natl Acad Sci U S A. 1989 Sep;86(18):7260-4. 2780570
  5. Yamazaki S, Nakanishi M, Hamamoto T, Hirata H, Ebihara A, Tokue A, Kagawa Y: Expression of human metallothionein-II fusion protein in Escherichia coli. Biochem Int. 1992 Nov;28(3):451-60. 1339282
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  7. Gauci S, Helbig AO, Slijper M, Krijgsveld J, Heck AJ, Mohammed S: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. Anal Chem. 2009 Jun 1;81(11):4493-501. doi: 10.1021/ac9004309. 19413330
  8. Bian Y, Song C, Cheng K, Dong M, Wang F, Huang J, Sun D, Wang L, Ye M, Zou H: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J Proteomics. 2014 Jan 16;96:253-62. doi: 10.1016/j.jprot.2013.11.014. Epub 2013 Nov 22. 24275569
  9. Messerle BA, Schaffer A, Vasak M, Kagi JH, Wuthrich K: Three-dimensional structure of human [113Cd7]metallothionein-2 in solution determined by nuclear magnetic resonance spectroscopy. J Mol Biol. 1990 Aug 5;214(3):765-79. 2388267
  10. Messerle BA, Schaffer A, Vasak M, Kagi JH, Wuthrich K: Comparison of the solution conformations of human [Zn7]-metallothionein-2 and [Cd7]-metallothionein-2 using nuclear magnetic resonance spectroscopy. J Mol Biol. 1992 May 20;225(2):433-43. 1593628