Superoxide dismutase [Mn], mitochondrial

NameSuperoxide dismutase [Mn], mitochondrial
Synonyms
  • 1.15.1.1
Gene NameSOD2
OrganismHuman
Amino acid sequence
>lcl|BSEQ0009374|Superoxide dismutase [Mn], mitochondrial
MLSRAVCGTSRQLAPALGYLGSRQKHSLPDLPYDYGALEPHINAQIMQLHHSKHHAAYVN
NLNVTEEKYQEALAKGDVTAQIALQPALKFNGGGHINHSIFWTNLSPNGGGEPKGELLEA
IKRDFGSFDKFKEKLTAASVGVQGSGWGWLGFNKERGHLQIAACPNQDPLQGTTGLIPLL
GIDVWEHAYYLQYKNVRPDYLKAIWNVINWENVTERYMACKK
Number of residues222
Molecular Weight24721.955
Theoretical pINot Available
GO Classification
Functions
  • manganese ion binding
  • superoxide dismutase activity
  • identical protein binding
Processes
  • negative regulation of neuron apoptotic process
  • regulation of transcription from RNA polymerase II promoter
  • response to reactive oxygen species
  • release of cytochrome c from mitochondria
  • oxygen homeostasis
  • age-dependent response to reactive oxygen species
  • negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
  • response to superoxide
  • superoxide metabolic process
  • removal of superoxide radicals
  • vasodilation by acetylcholine involved in regulation of systemic arterial blood pressure
  • negative regulation of cell proliferation
  • protein homotetramerization
  • regulation of blood pressure
Components
  • mitochondrion
  • mitochondrial matrix
  • extracellular exosome
General FunctionSuperoxide dismutase activity
Specific FunctionDestroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein IDNot Available
UniProtKB IDP04179
UniProtKB Entry NameSODM_HUMAN
Cellular LocationMitochondrion matrix
Gene sequence
>lcl|BSEQ0013118|Superoxide dismutase [Mn], mitochondrial (SOD2)
ATGTTGAGCCGGGCAGTGTGCGGCACCAGCAGGCAGCTGGCTCCGGTTTTGGGGTATCTG
GGCTCCAGGCAGAAGCACAGCCTCCCCGACCTGCCCTACGACTACGGCGCCCTGGAACCT
CACATCAACGCGCAGATCATGCAGCTGCACCACAGCAAGCACCACGCGGCCTACGTGAAC
AACCTGAACGTCACCGAGGAGAAGTACCAGGAGGCGTTGGCCAAGGGAGATGTTACAGCC
CAGATAGCTCTTCAGCCTGCACTGAAGTTCAATGGTGGTGGTCATATCAATCATAGCATT
TTCTGGACAAACCTCAGCCCTAACGGTGGTGGAGAACCCAAAGGGGAGTTGCTGGAAGCC
ATCAAACGTGACTTTGGTTCCTTTGACAAGTTTAAGGAGAAGCTGACGGCTGCATCTGTT
GGTGTCCAAGGCTCAGGTTGGGGTTGGCTTGGTTTCAATAAGGAACGGGGACACTTACAA
ATTGCTGCTTGTCCAAATCAGGATCCACTGCAAGGAACAACAGGCCTTATTCCACTGCTG
GGGATTGATGTGTGGGAGCACGCTTACTACCTTCAGTATAAAAATGTCAGGCCTGATTAT
CTAAAAGCTATTTGGAATGTAATCAACTGGGAGAATGTAACTGAAAGATACATGGCTTGC
AAAAAGTAA
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:11180
Chromosome Location6
LocusNot Available
References
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