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NameSemenogelin-1
Synonyms
  • Cancer/testis antigen 103
  • Semenogelin I
  • SEMG
  • SGI
Gene NameSEMG1
OrganismHuman
Amino acid sequence
>lcl|BSEQ0009862|Semenogelin-1
MKPNIIFVLSLLLILEKQAAVMGQKGGSKGRLPSEFSQFPHGQKGQHYSGQKGKQQTESK
GSFSIQYTYHVDANDHDQSRKSQQYDLNALHKTTKSQRHLGGSQQLLHNKQEGRDHDKSK
GHFHRVVIHHKGGKAHRGTQNPSQDQGNSPSGKGISSQYSNTEERLWVHGLSKEQTSVSG
AQKGRKQGGSQSSYVLQTEELVANKQQRETKNSHQNKGHYQNVVEVREEHSSKVQTSLCP
AHQDKLQHGSKDIFSTQDELLVYNKNQHQTKNLNQDQQHGRKANKISYQSSSTEERRLHY
GENGVQKDVSQSSIYSQTEEKAQGKSQKQITIPSQEQEHSQKANKISYQSSSTEERRLHY
GENGVQKDVSQRSIYSQTEKLVAGKSQIQAPNPKQEPWHGENAKGESGQSTNREQDLLSH
EQKGRHQHGSHGGLDIVIIEQEDDSDRHLAQHLNNDRNPLFT
Number of residues462
Molecular Weight52130.885
Theoretical pINot Available
GO Classification
Functions
  • structural molecule activity
  • metal ion binding
Processes
  • cellular protein metabolic process
  • protein heterooligomerization
  • antibacterial humoral response
  • insemination
  • negative regulation of sperm motility
  • coagulation
  • negative regulation of calcium ion import
  • positive regulation of serine-type endopeptidase activity
Components
  • protein complex
  • extracellular region
  • nucleus
  • extracellular space
  • extracellular exosome
  • secretory granule
General FunctionStructural molecule activity
Specific FunctionPredominant protein in semen. It participates in the formation of a gel matrix entrapping the accessory gland secretions and ejaculated spermatozoa. Fragments of semenogelin and/or fragments of the related proteins may contribute to the activation of progressive sperm movements as the gel-forming proteins are fragmented by KLK3/PSA.Alpha-inhibin-92 and alpha-inhibin-31, derived from the proteolytic degradation of semenogelin, inhibit the secretion of pituitary follicle-stimulating hormone.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein IDNot Available
UniProtKB IDP04279
UniProtKB Entry NameSEMG1_HUMAN
Cellular LocationSecreted
Gene sequence
>lcl|BSEQ0020903|Semenogelin-1 (SEMG1)
ATGAAGCCCAACATCATCTTTGTACTTTCCCTGCTCCTCATCTTGGAGAAGCAAGCAGCT
GTGATGGGACAAAAAGGTGGATCAAAAGGCCGATTACCAAGTGAATTTTCCCAATTTCCA
CACGGACAAAAGGGCCAGCACTATTCTGGACAAAAAGGCAAGCAACAAACTGAATCCAAA
GGCAGTTTTTCTATTCAATACACATATCATGTAGATGCCAATGATCATGACCAGTCCCGA
AAAAGTCAGCAATATGATTTGAATGCCCTACATAAGACGACAAAATCACAACGACATCTA
GGTGGAAGTCAACAACTGCTCCATAATAAACAAGAAGGCAGAGACCATGATAAATCAAAA
GGTCATTTTCACAGGGTAGTTATACACCATAAAGGAGGCAAAGCTCATCGTGGGACACAA
AATCCTTCTCAAGATCAGGGGAATAGCCCATCTGGAAAGGGAATATCCAGTCAATATTCA
AACACAGAAGAAAGGCTGTGGGTTCATGGACTAAGTAAAGAACAAACTTCCGTCTCTGGT
GCACAAAAAGGTAGAAAACAAGGCGGATCCCAAAGCAGTTATGTTCTCCAAACTGAAGAG
CTAGTAGCTAACAAACAACAACGTGAGACTAAAAATTCTCATCAAAATAAAGGGCATTAC
CAAAATGTGGTTGAAGTGAGAGAGGAACATTCAAGTAAAGTACAAACCTCACTCTGTCCT
GCGCACCAAGACAAACTCCAACATGGATCCAAAGACATTTTTTCTACCCAAGATGAGCTC
CTAGTATATAACAAGAATCAACACCAGACAAAAAATCTCAATCAAGATCAACAGCATGGC
CGAAAGGCAAATAAAATATCATACCAATCTTCAAGTACAGAAGAAAGACGACTCCACTAT
GGAGAAAATGGTGTGCAGAAAGATGTATCCCAAAGCAGTATTTATAGCCAAACTGAAGAG
AAAGCACAGGGCAAGTCTCAAAAACAGATAACAATTCCCAGTCAAGAGCAAGAGCATAGC
CAAAAGGCAAATAAAATATCATACCAATCTTCAAGTACGGAAGAAAGACGACTCCACTAT
GGAGAAAATGGTGTGCAGAAAGATGTATCCCAACGCAGTATTTATAGCCAAACTGAAAAG
CTAGTAGCAGGCAAGTCTCAAATCCAGGCACCAAATCCTAAGCAAGAGCCATGGCATGGT
GAAAATGCAAAAGGAGAGTCTGGCCAATCTACAAATAGAGAACAAGACCTACTCAGTCAT
GAACAAAAAGGCAGACACCAACATGGATCTCATGGGGGATTGGATATTGTAATTATAGAG
CAGGAAGATGACAGTGATCGTCATTTGGCACAACATCTTAACAACGACCGAAACCCATTA
TTTACATAA
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:10742
Chromosome Location20
LocusNot Available
References
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  2. Ulvsback M, Lazure C, Lilja H, Spurr NK, Rao VV, Loffler C, Hansmann I, Lundwall A: Gene structure of semenogelin I and II. The predominant proteins in human semen are encoded by two homologous genes on chromosome 20. J Biol Chem. 1992 Sep 5;267(25):18080-4. 1517240
  3. Jensen-Seaman MI, Li WH: Evolution of the hominoid semenogelin genes, the major proteins of ejaculated semen. J Mol Evol. 2003 Sep;57(3):261-70. 14629036
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  6. Kingan SB, Tatar M, Rand DM: Reduced polymorphism in the chimpanzee semen coagulating protein, semenogelin I. J Mol Evol. 2003 Aug;57(2):159-69. 14562960
  7. Lilja H, Jeppsson JO: Amino acid sequence of the predominant basic protein in human seminal plasma. FEBS Lett. 1985 Mar 11;182(1):181-4. 3972122
  8. Seidah NG, Ramasharma K, Sairam MR, Chretien M: Partial amino acid sequence of a human seminal plasma peptide with inhibin-like activity. FEBS Lett. 1984 Feb 13;167(1):98-102. 6698208
  9. Ramasharma K, Sairam MR, Seidah NG, Chretien M, Manjunath P, Schiller PW, Yamashiro D, Li CH: Isolation, structure, and synthesis of a human seminal plasma peptide with inhibin-like activity. Science. 1984 Mar 16;223(4641):1199-202. 6422553
  10. Schneider K, Kausler W, Tripier D, Jouvenal K, Spiteller G: [Isolation and structure determination of two peptides occurring in human seminal plasma]. Biol Chem Hoppe Seyler. 1989 Apr;370(4):353-6. 2757795
  11. Khan Z, Smyth DG: Isolation and identification of N-terminally extended forms of 5-oxoprolylglutamylprolinamide (Glp-Glu-Pro-NH2), a thyrotropin-releasing-hormone (TRH)-like peptide present in human semen. Eur J Biochem. 1993 Feb 15;212(1):35-40. 8444163
  12. Li CH, Hammonds RG Jr, Ramasharma K, Chung D: Human seminal alpha inhibins: isolation, characterization, and structure. Proc Natl Acad Sci U S A. 1985 Jun;82(12):4041-4. 3889920
  13. Robert M, Gagnon C: Semenogelin I: a coagulum forming, multifunctional seminal vesicle protein. Cell Mol Life Sci. 1999 Jun;55(6-7):944-60. 10412373
  14. Wang Z, Widgren EE, Sivashanmugam P, O'Rand MG, Richardson RT: Association of eppin with semenogelin on human spermatozoa. Biol Reprod. 2005 May;72(5):1064-70. Epub 2004 Dec 8. 15590901
  15. Wang Z, Widgren EE, Richardson RT, O'Rand MG: Characterization of an eppin protein complex from human semen and spermatozoa. Biol Reprod. 2007 Sep;77(3):476-84. Epub 2007 Jun 13. 17567961
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