Heat shock protein beta-1

NameHeat shock protein beta-1
Synonyms
  • 28 kDa heat shock protein
  • Estrogen-regulated 24 kDa protein
  • Heat shock 27 kDa protein
  • HSP 27
  • HSP27
  • HSP28
  • HspB1
  • SRP27
  • Stress-responsive protein 27
Gene NameHSPB1
OrganismHuman
Amino acid sequence
>lcl|BSEQ0006696|Heat shock protein beta-1
MTERRVPFSLLRGPSWDPFRDWYPHSRLFDQAFGLPRLPEEWSQWLGGSSWPGYVRPLPP
AAIESPAVAAPAYSRALSRQLSSGVSEIRHTADRWRVSLDVNHFAPDELTVKTKDGVVEI
TGKHEERQDEHGYISRCFTRKYTLPPGVDPTQVSSSLSPEGTLTVEAPMPKLATQSNEIT
IPVTFESRAQLGGPEAAKSDETAAK
Number of residues205
Molecular Weight22782.3
Theoretical pI6.36
GO Classification
Functions
  • poly(A) RNA binding
  • protein kinase C inhibitor activity
  • identical protein binding
  • ubiquitin binding
  • protein kinase binding
  • protein kinase C binding
Processes
  • positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway
  • regulation of translational initiation
  • positive regulation of angiogenesis
  • positive regulation of interleukin-1 beta production
  • negative regulation of protein kinase activity
  • response to virus
  • gene expression
  • cellular response to vascular endothelial growth factor stimulus
  • regulation of mRNA stability
  • retina homeostasis
  • positive regulation of endothelial cell chemotaxis
  • negative regulation of apoptotic process
  • vascular endothelial growth factor receptor signaling pathway
  • regulation of I-kappaB kinase/NF-kappaB signaling
  • intracellular signal transduction
  • response to unfolded protein
  • platelet aggregation
  • positive regulation of tumor necrosis factor biosynthetic process
  • movement of cell or subcellular component
  • positive regulation of blood vessel endothelial cell migration
  • negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
Components
  • nucleus
  • focal adhesion
  • plasma membrane
  • extracellular space
  • proteasome complex
  • cytosol
  • extracellular exosome
  • spindle
  • cytoplasm
  • cytoskeleton
  • Z disc
General FunctionUbiquitin binding
Specific FunctionInvolved in stress resistance and actin organization.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein IDNot Available
UniProtKB IDP04792
UniProtKB Entry NameHSPB1_HUMAN
Cellular LocationCytoplasm
Gene sequence
>lcl|BSEQ0020686|Heat shock protein beta-1 (HSPB1)
ATGACCGAGCGCCGCGTCCCCTTCTCGCTCCTGCGGGGCCCCAGCTGGGACCCCTTCCGC
GACTGGTACCCGCATAGCCGCCTCTTCGACCAGGCCTTCGGGCTGCCCCGGCTGCCGGAG
GAGTGGTCGCAGTGGTTAGGCGGCAGCAGCTGGCCAGGCTACGTGCGCCCCCTGCCCCCC
GCCGCCATCGAGAGCCCCGCAGTGGCCGCGCCCGCCTACAGCCGCGCGCTCAGCCGGCAA
CTCAGCAGCGGGGTCTCGGAGATCCGGCACACTGCGGACCGCTGGCGCGTGTCCCTGGAT
GTCAACCACTTCGCCCCGGACGAGCTGACGGTCAAGACCAAGGATGGCGTGGTGGAGATC
ACCGGCAAGCACGAGGAGCGGCAGGACGAGCATGGCTACATCTCCCGGTGCTTCACGCGG
AAATACACGCTGCCCCCCGGTGTGGACCCCACCCAAGTTTCCTCCTCCCTGTCCCCTGAG
GGCACACTGACCGTGGAGGCCCCCATGCCCAAGCTAGCCACGCAGTCCAACGAGATCACC
ATCCCAGTCACCTTCGAGTCGCGGGCCCAGCTTGGGGGCCCAGAAGCTGCAAAATCCGAT
GAGACTGCCGCCAAGTAA
GenBank Gene IDL39370
GeneCard IDNot Available
GenAtlas IDHSPB1
HGNC IDHGNC:5246
Chromosome Location7
LocusNot Available
References
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