Alpha-enolase

NameAlpha-enolase
Synonyms
  • 2-phospho-D-glycerate hydro-lyase
  • 4.2.1.11
  • C-myc promoter-binding protein
  • ENO1L1
  • Enolase 1
  • MBP-1
  • MBPB1
  • MPB-1
  • MPB1
  • NNE
  • Non-neural enolase
  • Phosphopyruvate hydratase
  • Plasminogen-binding protein
Gene NameENO1
OrganismHuman
Amino acid sequence
>lcl|BSEQ0009836|Alpha-enolase
MSILKIHAREIFDSRGNPTVEVDLFTSKGLFRAAVPSGASTGIYEALELRDNDKTRYMGK
GVSKAVEHINKTIAPALVSKKLNVTEQEKIDKLMIEMDGTENKSKFGANAILGVSLAVCK
AGAVEKGVPLYRHIADLAGNSEVILPVPAFNVINGGSHAGNKLAMQEFMILPVGAANFRE
AMRIGAEVYHNLKNVIKEKYGKDATNVGDEGGFAPNILENKEGLELLKTAIGKAGYTDKV
VIGMDVAASEFFRSGKYDLDFKSPDDPSRYISPDQLADLYKSFIKDYPVVSIEDPFDQDD
WGAWQKFTASAGIQVVGDDLTVTNPKRIAKAVNEKSCNCLLLKVNQIGSVTESLQACKLA
QANGWGVMVSHRSGETEDTFIADLVVGLCTGQIKTGAPCRSERLAKYNQLLRIEEELGSK
AKFAGRNFRNPLAK
Number of residues434
Molecular Weight47168.555
Theoretical pINot Available
GO Classification
Functions
  • GTPase binding
  • transcription corepressor activity
  • DNA binding
  • transcription factor activity, sequence-specific DNA binding
  • poly(A) RNA binding
  • magnesium ion binding
  • phosphopyruvate hydratase activity
Processes
  • small molecule metabolic process
  • carbohydrate metabolic process
  • glucose metabolic process
  • negative regulation of transcription from RNA polymerase II promoter
  • transcription, DNA-templated
  • response to virus
  • canonical glycolysis
  • gluconeogenesis
  • negative regulation of transcription, DNA-templated
  • negative regulation of cell growth
Components
  • cytosol
  • extracellular exosome
  • cytoplasm
  • membrane
  • nucleus
  • plasma membrane
  • extracellular space
  • phosphopyruvate hydratase complex
  • M band
General FunctionTranscription factor activity, sequence-specific dna binding
Specific FunctionMultifunctional enzyme that, as well as its role in glycolysis, plays a part in various processes such as growth control, hypoxia tolerance and allergic responses. May also function in the intravascular and pericellular fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the cell surface of several cell-types such as leukocytes and neurons. Stimulates immunoglobulin production.MBP1 binds to the myc promoter and acts as a transcriptional repressor. May be a tumor suppressor.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein IDNot Available
UniProtKB IDP06733
UniProtKB Entry NameENOA_HUMAN
Cellular LocationCytoplasm
Gene sequence
>lcl|BSEQ0013940|Alpha-enolase (ENO1)
ATGATCGAGATGGATGGAACAGAAAATAAATCTAAGTTTGGTGCGAACGCCATTCTGGGG
GTGTCCCTTGCCGTCTGCAAAGCTGGTGCCGTTGAGAAGGGGGTCCCCCTGTACCGCCAC
ATCGCTGACTTGGCTGGCAACTCTGAAGTCATCCTGCCAGTCCCGGCGTTCAATGTCATC
AATGGCGGTTCTCATGCTGGCAACAAGCTGGCCATGCAGGAGTTCATGATCCTCCCAGTC
GGTGCAGCAAACTTCAGGGAAGCCATGCGCATTGGAGCAGAGGTTTACCACAACCTGAAG
AATGTCATCAAGGAGAAATATGGGAAAGATGCCACCAATGTGGGGGATGAAGGCGGGTTT
GCTCCCAACATCCTGGAGAATAAAGAAGGCCTGGAGCTGCTGAAGACTGCTATTGGGAAA
GCTGGCTACACTGATAAGGTGGTCATCGGCATGGACGTAGCGGCCTCCGAGTTCTTCAGG
TCTGGGAAGTATGACCTGGACTTCAAGTCTCCCGATGACCCCAGCAGGTACATCTCGCCT
GACCAGCTGGCTGACCTGTACAAGTCCTTCATCAAGGACTACCCAGTGGTGTCTATCGAA
GATCCCTTTGACCAGGATGACTGGGGAGCTTGGCAGAAGTTCACAGCCAGTGCAGGAATC
CAGGTAGTGGGGGATGATCTCACAGTGACCAACCCAAAGAGGATCGCCAAGGCCGTGAAC
GAGAAGTCCTGCAACTGCCTCCTGCTCAAAGTCAACCAGATTGGCTCCGTGACCGAGTCT
CTTCAGGCGTGCAAGCTGGCCCAGGCCAATGGTTGGGGCGTCATGGTGTCTCATCGTTCG
GGGGAGACTGAAGATACCTTCATCGCTGACCTGGTTGTGGGGCTGTGCACTGGGCAGATC
AAGACTGGTGCCCCTTGCCGATCTGAGCGCTTGGCCAAGTACAACCAGCTCCTCAGAATT
GAAGAGGAGCTGGGCAGCAAGGCTAAGTTTGCCGGCAGGAACTTCAGAAACCCCTTGGCC
AAGTAA
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:3350
Chromosome Location1
LocusNot Available
References
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