Integrin alpha-V

NameIntegrin alpha-V
Synonyms
  • MSK8
  • Vitronectin receptor subunit alpha
  • VNRA
Gene NameITGAV
OrganismHuman
Amino acid sequence
>lcl|BSEQ0006887|Integrin alpha-V
MAFPPRRRLRLGPRGLPLLLSGLLLPLCRAFNLDVDSPAEYSGPEGSYFGFAVDFFVPSA
SSRMFLLVGAPKANTTQPGIVEGGQVLKCDWSSTRRCQPIEFDATGNRDYAKDDPLEFKS
HQWFGASVRSKQDKILACAPLYHWRTEMKQEREPVGTCFLQDGTKTVEYAPCRSQDIDAD
GQGFCQGGFSIDFTKADRVLLGGPGSFYWQGQLISDQVAEIVSKYDPNVYSIKYNNQLAT
RTAQAIFDDSYLGYSVAVGDFNGDGIDDFVSGVPRAARTLGMVYIYDGKNMSSLYNFTGE
QMAAYFGFSVAATDINGDDYADVFIGAPLFMDRGSDGKLQEVGQVSVSLQRASGDFQTTK
LNGFEVFARFGSAIAPLGDLDQDGFNDIAIAAPYGGEDKKGIVYIFNGRSTGLNAVPSQI
LEGQWAARSMPPSFGYSMKGATDIDKNGYPDLIVGAFGVDRAILYRARPVITVNAGLEVY
PSILNQDNKTCSLPGTALKVSCFNVRFCLKADGKGVLPRKLNFQVELLLDKLKQKGAIRR
ALFLYSRSPSHSKNMTISRGGLMQCEELIAYLRDESEFRDKLTPITIFMEYRLDYRTAAD
TTGLQPILNQFTPANISRQAHILLDCGEDNVCKPKLEVSVDSDQKKIYIGDDNPLTLIVK
AQNQGEGAYEAELIVSIPLQADFIGVVRNNEALARLSCAFKTENQTRQVVCDLGNPMKAG
TQLLAGLRFSVHQQSEMDTSVKFDLQIQSSNLFDKVSPVVSHKVDLAVLAAVEIRGVSSP
DHVFLPIPNWEHKENPETEEDVGPVVQHIYELRNNGPSSFSKAMLHLQWPYKYNNNTLLY
ILHYDIDGPMNCTSDMEINPLRIKISSLQTTEKNDTVAGQGERDHLITKRDLALSEGDIH
TLGCGVAQCLKIVCQVGRLDRGKSAILYVKSLLWTETFMNKENQNHSYSLKSSASFNVIE
FPYKNLPIEDITNSTLVTTNVTWGIQPAPMPVPVWVIILAVLAGLLLLAVLVFVMYRMGF
FKRVRPPQEEQEREQLQPHENGEGNSET
Number of residues1048
Molecular Weight116036.855
Theoretical pI5.36
GO Classification
Functions
  • virus receptor activity
  • fibronectin binding
  • protease binding
  • voltage-gated calcium channel activity
  • transforming growth factor beta binding
  • extracellular matrix protein binding
  • extracellular matrix binding
  • metal ion binding
Processes
  • apolipoprotein A-I-mediated signaling pathway
  • negative regulation of lipoprotein metabolic process
  • positive regulation of cell adhesion
  • negative regulation of macrophage derived foam cell differentiation
  • negative regulation of low-density lipoprotein particle receptor biosynthetic process
  • heterotypic cell-cell adhesion
  • axon guidance
  • regulation of apoptotic cell clearance
  • substrate adhesion-dependent cell spreading
  • regulation of phagocytosis
  • cell migration
  • ERK1 and ERK2 cascade
  • extrinsic apoptotic signaling pathway in absence of ligand
  • extracellular matrix organization
  • positive regulation of osteoblast proliferation
  • negative regulation of extrinsic apoptotic signaling pathway
  • leukocyte migration
  • cell adhesion
  • positive regulation of cell migration
  • blood coagulation
  • vascular endothelial growth factor receptor signaling pathway
  • positive regulation of cell proliferation
  • apoptotic cell clearance
  • antigen processing and presentation of exogenous peptide antigen via MHC class I
  • cell-substrate adhesion
  • entry of symbiont into host cell by promotion of host phagocytosis
  • viral entry into host cell
  • integrin-mediated signaling pathway
  • cell-matrix adhesion
  • negative chemotaxis
  • endodermal cell differentiation
  • calcium ion transmembrane transport
  • negative regulation of entry of bacterium into host cell
  • angiogenesis
  • cell growth
  • negative regulation of lipid storage
  • antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
  • negative regulation of lipid transport
  • antigen processing and presentation of peptide antigen via MHC class I
Components
  • cell surface
  • extracellular exosome
  • focal adhesion
  • external side of plasma membrane
  • integral component of plasma membrane
  • microvillus membrane
  • membrane
  • filopodium membrane
  • lamellipodium membrane
  • alphav-beta3 integrin-IGF-1-IGF1R complex
  • ruffle membrane
  • integrin alphav-beta3 complex
  • plasma membrane
  • integrin alphav-beta5 complex
  • integrin alphav-beta8 complex
  • integrin complex
  • phagocytic vesicle
General FunctionVoltage-gated calcium channel activity
Specific FunctionThe alpha-V (ITGAV) integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF. They recognize the sequence R-G-D in a wide array of ligands.(Microbial infection) Integrin ITGAV:ITGB5 acts as a receptor for adenovirus type C (PubMed:20615244). Integrin ITGAV:ITGB5 and ITGAV:ITGB3 act as receptors for coxsackievirus A9 and B1 (PubMed:9426447, PubMed:15194773, PubMed:7519807). Integrin ITGAV:ITGB3 acts as a receptor for herpes virus 8/HHV-8 (PubMed:18045938). Integrin ITGAV:ITGB6 acts as a receptor for herpes simplex 1/HHV-1 (PubMed:24367260). Integrin ITGAV:ITGB3 acts as a receptor for Human parechovirus 1 (PubMed:11160695). Integrin ITGAV:ITGB3 acts as a receptor for West nile virus (PubMed:23658209). In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions (PubMed:10397733).
Pfam Domain Function
Transmembrane Regions993-1016
GenBank Protein ID340307
UniProtKB IDP06756
UniProtKB Entry NameITAV_HUMAN
Cellular LocationMembrane
Gene sequence
>lcl|BSEQ0012486|Integrin alpha-V (ITGAV)
ATGCTCCTAGGCACCCTCCTTCTGATCCTGTACATCTTAATGTTGTGCCGGATGTTTCTT
CTCGTGGGAGCTCCCAAAGCAAACACCACCCAGCCTGGGATTGTGGAAGGAGGGCAGGTC
CTCAAATGTGACTGGTCTTCTACCCGCCGGTGCCAGCCAATTGAATTTGATGCAACAGGC
AATAGAGATTATGCCAAGGATGATCCATTGGAATTTAAGTCCCATCAGTGGTTTGGAGCA
TCTGTGAGGTCGAAACAGGATAAAATTTTGGCCTGTGCCCCATTGTACCATTGGAGAACT
GAGATGAAACAGGAGCGAGAGCCTGTTGGAACATGCTTTCTTCAAGATGGAACAAAGACT
GTTGAGTATGCTCCATGTAGATCACAAGATATTGATGCTGATGGACAGGGATTTTGTCAA
GGAGGATTCAGCATTGATTTTACTAAAGCTGACAGAGTACTTCTTGGTGGTCCTGGTAGC
TTTTATTGGCAAGGTCAGCTTATTTCGGATCAAGTGGCAGAAATCGTATCTAAATACGAC
CCCAATGTTTACAGCATCAAGTATAATAACCAATTAGCAACTCGGACTGCACAAGCTATT
TTTGATGACAGCTATTTGGGTTATTCTGTGGCTGTCGGAGATTTCAATGGTGATGGCATA
GATGACTTTGTTTCAGGAGTTCCAAGAGCAGCAAGGACTTTGGGAATGGTTTATATTTAT
GATGGGAAGAACATGTCCTCCTTATACAATTTTACTGGCGAGCAGATGGCTGCATATTTC
GGATTTTCTGTAGCTGCCACTGACATTAATGGAGATGATTATGCAGATGTGTTTATTGGA
GCACCTCTCTTCATGGATCGTGGCTCTGATGGCAAACTCCAAGAGGTGGGGCAGGTCTCA
GTGTCTCTACAGAGAGCTTCAGGAGACTTCCAGACGACAAAGCTGAATGGATTTGAGGTC
TTTGCACGGTTTGGCAGTGCCATAGCTCCTTTGGGAGATCTGGACCAGGATGGTTTCAAT
GATATTGCAATTGCTGCTCCATATGGGGGTGAAGATAAAAAAGGAATTGTTTATATCTTC
AATGGAAGATCAACAGGCTTGAACGCAGTCCCATCTCAAATCCTTGAAGGGCAGTGGGCT
GCTCGAAGCATGCCACCAAGCTTTGGCTATTCAATGAAAGGAGCCACAGATATAGACAAA
AATGGATATCCAGACTTAATTGTAGGAGCTTTTGGTGTAGATCGAGCTATCTTATACAGG
GCCAGACCAGTTATCACTGTAAATGCTGGTCTTGAAGTGTACCCTAGCATTTTAAATCAA
GACAATAAAACCTGCTCACTGCCTGGAACAGCTCTCAAAGTTTCCTGTTTTAATGTTAGG
TTCTGCTTAAAGGCAGATGGCAAAGGAGTACTTCCCAGGAAACTTAATTTCCAGGTGGAA
CTTCTTTTGGATAAACTCAAGCAAAAGGGAGCAATTCGACGAGCACTGTTTCTCTACAGC
AGGTCCCCAAGTCACTCCAAGAACATGACTATTTCAAGGGGGGGACTGATGCAGTGTGAG
GAATTGATAGCGTATCTGCGGGATGAATCTGAATTTAGAGACAAACTCACTCCAATTACT
ATTTTTATGGAATATCGGTTGGATTATAGAACAGCTGCTGATACAACAGGCTTGCAACCC
ATTCTTAACCAGTTCACGCCTGCTAACATTAGTCGACAGGCTCACATTCTACTTGACTGT
GGTGAAGACAATGTCTGTAAACCCAAGCTGGAAGTTTCTGTAGATAGTGATCAAAAGAAG
ATCTATATTGGGGATGACAACCCTCTGACATTGATTGTTAAGGCTCAGAATCAAGGAGAA
GGTGCCTACGAAGCTGAGCTCATCGTTTCCATTCCACTGCAGGCTGATTTCATCGGGGTT
GTCCGAAACAATGAAGCCTTAGCAAGACTTTCCTGTGCATTTAAGACAGAAAACCAAACT
CGCCAGGTGGTATGTGACCTTGGAAACCCAATGAAGGCTGGAACTCAACTCTTAGCTGGT
CTTCGTTTCAGTGTGCACCAGCAGTCAGAGATGGATACTTCTGTGAAATTTGACTTACAA
ATCCAAAGCTCAAATCTATTTGACAAAGTAAGCCCAGTTGTATCTCACAAAGTTGATCTT
GCTGTTTTAGCTGCAGTTGAGATAAGAGGAGTCTCGAGTCCTGATCATATCTTTCTTCCG
ATTCCAAACTGGGAGCACAAGGAGAACCCTGAGACTGAAGAAGATGTTGGGCCAGTTGTT
CAGCACATCTATGAGCTGAGAAACAATGGTCCAAGTTCATTCAGCAAGGCAATGCTCCAT
CTTCAGTGGCCTTACAAATATAATAATAACACTCTGTTGTATATCCTTCATTATGATATT
GATGGACCAATGAACTGCACTTCAGATATGGAGATCAACCCTTTGAGAATTAAGATCTCA
TCTTTGCAAACAACTGAAAAGAATGACACGGTTGCCGGGCAAGGTGAGCGGGACCATCTC
ATCACTAAGCGGGATCTTGCCCTCAGTGAAGGAGATATTCACACTTTGGGTTGTGGAGTT
GCTCAGTGCTTGAAGATTGTCTGCCAAGTTGGGAGATTAGACAGAGGAAAGAGTGCAATC
TTGTACGTAAAGTCATTACTGTGGACTGAGACTTTTATGAATAAAGAAAATCAGAATCAT
TCCTATTCTCTGAAGTCGTCTGCTTCATTTAATGTCATAGAGTTTCCTTATAAGAATCTT
CCAATTGAGGATATCACCAACTCCACATTGGTTACCACTAATGTCACCTGGGGCATTCAG
CCAGCGCCCATGCCTGTGCCTGTGTGGGTGATCATTTTAGCAGTTCTAGCAGGATTGTTG
CTACTGGCTGTTTTGGTATTTGTAATGTACAGGATGGGCTTTTTTAAACGGGTCCGGCCA
CCTCAAGAAGAACAAGAAAGGGAGCAGCTTCAACCTCATGAAAATGGTGAAGGAAACTCA
GAAACTTAA
GenBank Gene IDM14648
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:6150
Chromosome Location2
Locus2q31-q32
References
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