Beta-2 adrenergic receptor

NameBeta-2 adrenergic receptor
Synonyms
  • ADRB2R
  • B2AR
  • Beta-2 adrenoceptor
  • Beta-2 adrenoreceptor
Gene NameADRB2
OrganismHuman
Amino acid sequence
>lcl|BSEQ0037061|Beta-2 adrenergic receptor
MGQPGNGSAFLLAPNGSHAPDHDVTQERDEVWVVGMGIVMSLIVLAIVFGNVLVITAIAK
FERLQTVTNYFITSLACADLVMGLAVVPFGAAHILMKMWTFGNFWCEFWTSIDVLCVTAS
IETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRATHQE
AINCYANETCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLQKIDKSEGRF
HVQNLSQVEQDGRTGHGLRRSSKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQD
NLIRKEVYILLNWIGYVNSGFNPLIYCRSPDFRIAFQELLCLRRSSLKAYGNGYSSNGNT
GEQSGYHVEQEKENKLLCEDLPGTEDFVGHQGTVPSDNIDSQGRNCSTNDSLL
Number of residues413
Molecular Weight46458.32
Theoretical pI7.44
GO Classification
Functions
  • norepinephrine binding
  • drug binding
  • beta2-adrenergic receptor activity
  • potassium channel regulator activity
  • dopamine binding
  • protein homodimerization activity
  • epinephrine binding
Processes
  • positive regulation of sodium ion transport
  • receptor-mediated endocytosis
  • response to dexamethasone
  • cellular response to hypoxia
  • activation of adenylate cyclase activity
  • negative regulation of platelet aggregation
  • adenylate cyclase-activating adrenergic receptor signaling pathway
  • positive regulation of bone mineralization
  • positive regulation of transcription from RNA polymerase II promoter
  • liver regeneration
  • brown fat cell differentiation
  • aging
  • wound healing
  • endosome to lysosome transport
  • diet induced thermogenesis
  • adenylate cyclase-modulating G-protein coupled receptor signaling pathway
  • cell surface receptor signaling pathway
  • positive regulation of ATPase activity
  • heat generation
  • negative regulation of urine volume
  • positive regulation of cell proliferation
  • negative regulation of smooth muscle contraction
  • negative regulation of multicellular organism growth
  • response to cold
  • positive regulation of protein ubiquitination
  • response to estrogen
  • desensitization of G-protein coupled receptor protein signaling pathway by arrestin
  • vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure
  • activation of transmembrane receptor protein tyrosine kinase activity
  • positive regulation of autophagosome maturation
  • mitophagy in response to mitochondrial depolarization
  • negative regulation of inflammatory response
  • positive regulation of lipophagy
  • positive regulation of vasodilation
  • excitatory postsynaptic potential
  • positive regulation of skeletal muscle tissue growth
  • regulation of calcium ion transport
  • positive regulation of the force of heart contraction by epinephrine
  • response to progesterone
  • estrous cycle
  • positive regulation of potassium ion transport
  • negative regulation of ossification
  • response to monoamine
  • synaptic transmission, glutamatergic
  • regulation of sensory perception of pain
  • female pregnancy
  • cell-cell signaling
  • response to testosterone
  • positive regulation of MAPK cascade
  • bone resorption
  • associative learning
  • positive regulation of apoptotic process
  • diaphragm contraction
  • negative regulation of angiogenesis
Components
  • nucleus
  • endosome
  • plasma membrane
  • dendritic spine
  • receptor complex
  • apical plasma membrane
  • lysosome
  • neuronal cell body membrane
  • axon
  • early endosome
  • sarcolemma
  • integral component of plasma membrane
General FunctionProtein homodimerization activity
Specific FunctionBeta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine.
Pfam Domain Function
Transmembrane Regions35-58 72-95 107-129 151-174 197-220 275-298 306-329
GenBank Protein ID29371
UniProtKB IDP07550
UniProtKB Entry NameADRB2_HUMAN
Cellular LocationCell membrane
Gene sequence
>lcl|BSEQ0020478|Beta-2 adrenergic receptor (ADRB2)
ATGGGGCAACCCGGGAACGGCAGCGCCTTCTTGCTGGCACCCAATAGAAGCCATGCGCCG
GACCACGACGTCACGCAGCAAAGGGACGAGGTGTGGGTGGTGGGCATGGGCATCGTCATG
TCTCTCATCGTCCTGGCCATCGTGTTTGGCAATGTGCTGGTCATCACAGCCATTGCCAAG
TTCGAGCGTCTGCAGACGGTCACCAACTACTTCATCACTTCACTGGCCTGTGCTGATCTG
GTCATGGGCCTGGCAGTGGTGCCCTTTGGGGCCGCCCATATTCTTATGAAAATGTGGACT
TTTGGCAACTTCTGGTGCGAGTTTTGGACTTCCATTGATGTGCTGTGCGTCACGGCCAGC
ATTGAGACCCTGTGCGTGATCGCAGTGGATCGCTACTTTGCCATTACTTCACCTTTCAAG
TACCAGAGCCTGCTGACCAAGAATAAGGCCCGGGTGATCATTCTGATGGTGTGGATTGTG
TCAGGCCTTACCTCCTTCTTGCCCATTCAGATGCACTGGTACCGGGCCACCCACCAGGAA
GCCATCAACTGCTATGCCAATGAGACCTGCTGTGACTTCTTCACGAACCAAGCCTATGCC
ATTGCCTCTTCCATCGTGTCCTTCTACGTTCCCCTGGTGATCATGGTCTTCGTCTACTCC
AGGGTCTTTCAGGAGGCCAAAAGGCAGCTCCAGAAGATTGACAAATCTGAGGGCCGCTTC
CATGTCCAGAACCTTAGCCAGGTGGAGCAGGATGGGCGGACGGGGCATGGACTCCGCAGA
TCTTCCAAGTTCTGCTTGAAGGAGCACAAAGCCCTCAAGACGTTAGGCATCATCATGGGC
ACTTTCACCCTCTGCTGGCTGCCCTTCTTCATCGTTAACATTGTGCATGTGATCCAGGAT
AACCTCATCCGTAAGGAAGTTTACATCCTCCTAAATTGGATAGGCTATGTCAATTCTGGT
TTCAATCCCCTTATCTACTGCCGGAGCCCAGATTTCAGGATTGCCTTCCAGGAGCTTCTG
TGCCTGCGCAGGTCTTCTTTGAAGGCCTATGGGAATGGCTACTCCAGCAACGGCAACACA
GGGGAGCAGAGTGGATATCACGTGGAACAGGAGAAAGAAAATAAACTGCTGTGTGAAGAC
CTCCCAGGCACGGAAGACTTTGTGGGCCATCAAGGTACTGTGCCTAGCGATAACATTGAT
TCACAAGGGAGGAATTGTAGTACAAATGACTCACTGCTGTAA
GenBank Gene IDY00106
GeneCard IDNot Available
GenAtlas IDADRB2
HGNC IDHGNC:286
Chromosome Location5
Locus5q31-q32
References
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