Tyrosine-protein kinase Lyn

NameTyrosine-protein kinase Lyn
Synonyms
  • 2.7.10.2
  • JTK8
  • Lck/Yes-related novel protein tyrosine kinase
  • p53Lyn
  • p56Lyn
  • V-yes-1 Yamaguchi sarcoma viral related oncogene homolog
Gene NameLYN
OrganismHuman
Amino acid sequence
>lcl|BSEQ0008201|Tyrosine-protein kinase Lyn
MGCIKSKGKDSLSDDGVDLKTQPVRNTERTIYVRDPTSNKQQRPVPESQLLPGQRFQTKD
PEEQGDIVVALYPYDGIHPDDLSFKKGEKMKVLEEHGEWWKAKSLLTKKEGFIPSNYVAK
LNTLETEEWFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVRDFDPVHGDVI
KHYKIRSLDNGGYYISPRITFPCISDMIKHYQKQADGLCRRLEKACISPKPQKPWDKDAW
EIPRESIKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHD
KLVRLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIER
KNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCF
TIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDELYDIMKMCW
KEKAEERPTFDYLQSVLDDFYTATEGQYQQQP
Number of residues512
Molecular Weight58573.595
Theoretical pI7.13
GO Classification
Functions
  • receptor binding
  • non-membrane spanning protein tyrosine kinase activity
  • enzyme binding
  • receptor signaling protein tyrosine kinase activity
  • ion channel binding
  • glycosphingolipid binding
  • ATP binding
  • protein tyrosine kinase activity
Processes
  • B cell receptor signaling pathway
  • negative regulation of mast cell proliferation
  • transmembrane receptor protein tyrosine kinase signaling pathway
  • regulation of mast cell activation
  • axon guidance
  • response to hormone
  • positive regulation of B cell receptor signaling pathway
  • negative regulation of myeloid leukocyte differentiation
  • blood coagulation
  • regulation of inflammatory response
  • negative regulation of B cell proliferation
  • cellular response to DNA damage stimulus
  • JAK-STAT cascade involved in growth hormone signaling pathway
  • cellular response to heat
  • positive regulation of dendritic cell apoptotic process
  • negative regulation of toll-like receptor 2 signaling pathway
  • Fc-gamma receptor signaling pathway involved in phagocytosis
  • ephrin receptor signaling pathway
  • positive regulation of neuron projection development
  • negative regulation of immune response
  • positive regulation of Fc receptor mediated stimulatory signaling pathway
  • response to drug
  • negative regulation of toll-like receptor 4 signaling pathway
  • innate immune response
  • negative regulation of protein phosphorylation
  • positive regulation of oligodendrocyte progenitor proliferation
  • response to toxic substance
  • regulation of mast cell degranulation
  • peptidyl-tyrosine autophosphorylation
  • regulation of cytokine production
  • positive regulation of stress-activated protein kinase signaling cascade
  • positive regulation of mast cell proliferation
  • viral process
  • regulation of B cell receptor signaling pathway
  • peptidyl-tyrosine phosphorylation
  • Fc-epsilon receptor signaling pathway
  • B cell homeostasis
  • positive regulation of tyrosine phosphorylation of STAT protein
  • response to insulin
  • positive regulation of cellular component movement
  • cellular response to retinoic acid
  • positive regulation of glial cell proliferation
  • regulation of B cell apoptotic process
  • platelet activation
  • neuron projection development
  • adaptive immune response
  • erythrocyte differentiation
  • leukocyte migration
  • cytokine secretion
  • regulation of monocyte chemotaxis
  • lipopolysaccharide-mediated signaling pathway
  • response to organic cyclic compound
  • regulation of cell adhesion mediated by integrin
  • positive regulation of cell migration
  • regulation of platelet aggregation
  • response to sterol depletion
  • regulation of ERK1 and ERK2 cascade
  • regulation of protein phosphorylation
  • negative regulation of cell proliferation
  • tolerance induction to self antigen
  • positive regulation of phosphatidylinositol 3-kinase activity
  • negative regulation of MAP kinase activity
  • immune response-regulating cell surface receptor signaling pathway
  • negative regulation of intracellular signal transduction
  • protein phosphorylation
  • regulation of erythrocyte differentiation
  • protein autophosphorylation
  • response to carbohydrate
  • regulation of cytokine secretion
  • stimulatory C-type lectin receptor signaling pathway
  • dendritic cell differentiation
  • response to axon injury
  • negative regulation of ERK1 and ERK2 cascade
  • platelet degranulation
  • signal transduction by protein phosphorylation
  • response to amino acid
  • cellular response to peptide hormone stimulus
  • Fc receptor mediated inhibitory signaling pathway
  • signal transduction
  • positive regulation of cell proliferation
  • oligodendrocyte development
  • cellular response to extracellular stimulus
  • regulation of release of sequestered calcium ion into cytosol
  • histamine secretion by mast cell
  • Fc receptor mediated stimulatory signaling pathway
  • T cell costimulation
Components
  • mitochondrial intermembrane space
  • nucleus
  • membrane raft
  • postsynaptic density
  • plasma membrane
  • mast cell granule
  • Golgi apparatus
  • cytosol
  • extracellular exosome
  • integrin alpha2-beta1 complex
  • cytoplasm
  • extrinsic component of cytoplasmic side of plasma membrane
  • perinuclear region of cytoplasm
  • cell-cell adherens junction
  • mitochondrial crista
General FunctionReceptor signaling protein tyrosine kinase activity
Specific FunctionNon-receptor tyrosine-protein kinase that transmits signals from cell surface receptors and plays an important role in the regulation of innate and adaptive immune responses, hematopoiesis, responses to growth factors and cytokines, integrin signaling, but also responses to DNA damage and genotoxic agents. Functions primarily as negative regulator, but can also function as activator, depending on the context. Required for the initiation of the B-cell response, but also for its down-regulation and termination. Plays an important role in the regulation of B-cell differentiation, proliferation, survival and apoptosis, and is important for immune self-tolerance. Acts downstream of several immune receptors, including the B-cell receptor, CD79A, CD79B, CD5, CD19, CD22, FCER1, FCGR2, FCGR1A, TLR2 and TLR4. Plays a role in the inflammatory response to bacterial lipopolysaccharide. Mediates the responses to cytokines and growth factors in hematopoietic progenitors, platelets, erythrocytes, and in mature myeloid cells, such as dendritic cells, neutrophils and eosinophils. Acts downstream of EPOR, KIT, MPL, the chemokine receptor CXCR4, as well as the receptors for IL3, IL5 and CSF2. Plays an important role in integrin signaling. Regulates cell proliferation, survival, differentiation, migration, adhesion, degranulation, and cytokine release. Down-regulates signaling pathways by phosphorylation of immunoreceptor tyrosine-based inhibitory motifs (ITIM), that then serve as binding sites for phosphatases, such as PTPN6/SHP-1, PTPN11/SHP-2 and INPP5D/SHIP-1, that modulate signaling by dephosphorylation of kinases and their substrates. Phosphorylates LIME1 in response to CD22 activation. Phosphorylates BTK, CBL, CD5, CD19, CD72, CD79A, CD79B, CSF2RB, DOK1, HCLS1, LILRB3/PIR-B, MS4A2/FCER1B, PTK2B/PYK2, SYK and TEC. Promotes phosphorylation of SIRPA, PTPN6/SHP-1, PTPN11/SHP-2 and INPP5D/SHIP-1. Mediates phosphorylation of the BCR-ABL fusion protein. Required for rapid phosphorylation of FER in response to FCER1 activation. Mediates KIT phosphorylation. Acts as an effector of EPOR (erythropoietin receptor) in controlling KIT expression and may play a role in erythroid differentiation during the switch between proliferation and maturation. Depending on the context, activates or inhibits several signaling cascades. Regulates phosphatidylinositol 3-kinase activity and AKT1 activation. Regulates activation of the MAP kinase signaling cascade, including activation of MAP2K1/MEK1, MAPK1/ERK2, MAPK3/ERK1, MAPK8/JNK1 and MAPK9/JNK2. Mediates activation of STAT5A and/or STAT5B. Phosphorylates LPXN on 'Tyr-72'. Kinase activity facilitates TLR4-TLR6 heterodimerization and signal initiation.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID307144
UniProtKB IDP07948
UniProtKB Entry NameLYN_HUMAN
Cellular LocationCell membrane
Gene sequence
>lcl|BSEQ0017409|Tyrosine-protein kinase Lyn (LYN)
ATGGGATGTATAAAATCAAAAGGGAAAGACAGCTTGAGTGACGATGGAGTAGATTTGAAG
ACTCAACCAGTTCCAGAATCTCAGCTTTTACCTGGACAGAGGTTTCAAACTAAAGATCCA
GAGGAACAAGGAGACATTGTGGTAGCCTTGTACCCCTATGATGGCATCCACCCGGACGAC
TTGTCTTTCAAGAAAGGAGAGAAGATGAAAGTCCTGGAGGAGCATGGAGAATGGTGGAAA
GCAAAGTCCCTTTTAACAAAAAAAGAAGGCTTCATCCCCAGCAACTATGTGGCCAAACTC
AACACCTTAGAAACAGAAGAGTGGTTTTTCAAGGATATAACCAGGAAGGACGCAGAAAGG
CAGCTTTTGGCACCAGGAAATAGCGCTGGAGCTTTCCTTATTAGAGAAAGTGAAACATTA
AAAGGAAGCTTCTCTCTGTCTGTCAGAGACTTTGACCCTGTGCATGGTGATGTTATTAAG
CACTACAAAATTAGAAGTCTGGATAATGGGGGCTATTACATCTCTCCACGAATCACTTTT
CCCTGTATCAGCGACATGATTAAACATTACCAAAAGCAGGCAGATGGCTTGTGCAGAAGA
TTGGAGAAGGCTTGTATTAGTCCCAAGCCACAGAAGCCATGGGATAAAGATGCCTGGGAG
ATCCCCCGGGAGTCCATCAAGTTGGTGAAAAGGCTTGGCGCTGGGCAGTTTGGGGAAGTC
TGGATGGGTTACTATAACAACAGTACCAAGGTGGCTGTGAAAACCCTGAAGCCAGGAACT
ATGTCTGTGCAAGCCTTCCTGGAAGAAGCCAACCTCATGAAGACCCTGCAGCATGACAAG
CTCGTGAGGCTCTACGCTGTGGTCACCAGGGAGGAGCCCATTTACATCATCACCGAGTAC
ATGGCCAAGGGCAGTTTGCTGGATTTCCTGAAGAGCGATGAAGGTGGCAAAGTGCTGCTT
CCAAAGCTCATTGACTTTTCTGCTCAGATTGCAGAGGGAATGGCATACATCGAGCGGAAG
AACTACATTCACCGGGACCTGCGAGCAGCTAATGTTCTGGTCTCCGAGTCACTCATGTGC
AAAATTGCAGATTTTGGCCTTGCTAGAGTAATTGAAGATAATGAGTACACAGCAAGGGAA
GGTGCTAAGTTCCCTATTAAGTGGACGGCTCCAGAAGCAATCAACTTTGGATGTTTCACT
ATTAAGTCTGATGTGTGGTCCTTTGGAATCCTCCTATACGAAATTGTCACCTATGGGAAA
ATTCCCTACCCAGGGAGAACTAATGCCGACGTGATGACCGCCCTGTCCCAGGGCTACAGG
ATGCCCCGTGTGGAGAACTGCCCAGATGAGCTCTATGACATTATGAAAATGTGCTGGAAA
GAAAAGGCAGAAGAGAGACCAACGTTTGACTACTTACAGAGCGTCCTGGATGATTTCTAC
ACAGCCACGGAAGGGCAATACCAGCAGCAGCCTTAG
GenBank Gene IDM16038
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:6735
Chromosome Location8
Locus8q13
References
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