Fibroblast growth factor 2

NameFibroblast growth factor 2
Synonyms
  • Basic fibroblast growth factor
  • bFGF
  • FGF-2
  • FGFB
  • HBGF-2
  • Heparin-binding growth factor 2
Gene NameFGF2
OrganismHuman
Amino acid sequence
>lcl|BSEQ0037112|Fibroblast growth factor 2
MVGVGGGDVEDVTPRPGGCQISGRGARGCNGIPGAAAWEAALPRRRPRRHPSVNPRSRAA
GSPRTRGRRTEERPSGSRLGDRGRGRALPGGRLGGRGRGRAPERVGGRGRGRGTAAPRAA
PAARGSRPGPAGTMAAGSITTLPALPEDGGSGAFPPGHFKDPKRLYCKNGGFFLRIHPDG
RVDGVREKSDPHIKLQLQAEERGVVSIKGVCANRYLAMKEDGRLLASKCVTDECFFFERL
ESNNYNTYRSRKYTSWYVALKRTGQYKLGSKTGPGQKAILFLPMSAKS
Number of residues288
Molecular Weight30769.715
Theoretical pI10.01
GO Classification
Functions
  • fibroblast growth factor receptor binding
  • ligand-dependent nuclear receptor transcription coactivator activity
  • chemoattractant activity
  • growth factor activity
  • cytokine activity
  • heparin binding
Processes
  • axon guidance
  • regulation of endothelial cell chemotaxis to fibroblast growth factor
  • nervous system development
  • epidermal growth factor receptor signaling pathway
  • embryonic morphogenesis
  • positive regulation of cell proliferation
  • growth factor dependent regulation of skeletal muscle satellite cell proliferation
  • innate immune response
  • negative regulation of blood vessel endothelial cell migration
  • positive regulation of MAP kinase activity
  • inositol phosphate biosynthetic process
  • positive regulation of cell fate specification
  • Fc-epsilon receptor signaling pathway
  • release of sequestered calcium ion into cytosol
  • phosphatidylinositol-mediated signaling
  • positive regulation of endothelial cell chemotaxis to fibroblast growth factor
  • extracellular matrix organization
  • negative regulation of cell death
  • positive regulation of ERK1 and ERK2 cascade
  • positive regulation of sprouting angiogenesis
  • positive regulation of transcription, DNA-templated
  • positive regulation of cardiac muscle cell proliferation
  • positive regulation of phosphatidylinositol 3-kinase activity
  • activation of MAPKK activity
  • positive regulation of phospholipase C activity
  • regulation of angiogenesis
  • fibroblast growth factor receptor signaling pathway
  • positive chemotaxis
  • negative regulation of wound healing
  • insulin receptor signaling pathway
  • hyaluronan catabolic process
  • signal transduction
  • positive regulation of angiogenesis
  • MAPK cascade
  • branching involved in ureteric bud morphogenesis
  • activation of MAPK activity
  • neurotrophin TRK receptor signaling pathway
  • positive regulation of endothelial cell proliferation
  • positive regulation of transcription from RNA polymerase II promoter
  • phosphatidylinositol biosynthetic process
  • organ morphogenesis
  • Ras protein signal transduction
  • positive regulation of blood vessel endothelial cell migration
  • somatic stem cell population maintenance
  • cell migration involved in sprouting angiogenesis
  • small GTPase mediated signal transduction
  • chondroblast differentiation
  • vascular endothelial growth factor receptor signaling pathway
  • negative regulation of fibroblast migration
  • chemotaxis
  • positive regulation of cell division
  • wound healing
Components
  • extracellular region
  • nucleus
  • extracellular space
General FunctionLigand-dependent nuclear receptor transcription coactivator activity
Specific FunctionPlays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID31362
UniProtKB IDP09038
UniProtKB Entry NameFGF2_HUMAN
Cellular LocationSecreted
Gene sequence
>lcl|BSEQ0021843|Fibroblast growth factor 2 (FGF2)
CTGGTGGGTGTGGGGGGTGGAGATGTAGAAGATGTGACGCCGCGGCCCGGCGGGTGCCAG
ATTAGCGGACGCGGTGCCCGCGGTTGCAACGGGATCCCGGGCGCTGCAGCTTGGGAGGCG
GCTCTCCCCAGGCGGCGTCCGCGGAGACACCCATCCGTGAACCCCAGGTCCCGGGCCGCC
GGCTCGCCGCGCACCAGGGGCCGGCGGACAGAAGAGCGGCCGAGCGGCTCGAGGCTGGGG
GACCGCGGGCGCGGCCGCGCGCTGCCGGGCGGGAGGCTGGGGGGCCGGGGCCGGGGCCGT
GCCCCGGAGCGGGTCGGAGGCCGGGGCCGGGGCCGGGGGACGGCGGCTCCCCGCGCGGCT
CCAGCGGCTCGGGGATCCCGGCCGGGCCCCGCAGGGACCATGGCAGCCGGGAGCATCACC
ACGCTGCCCGCCTTGCCCGAGGATGGCGGCAGCGGCGCCTTCCCGCCCGGCCACTTCAAG
GACCCCAAGCGGCTGTACTGCAAAAACGGGGGCTTCTTCCTGCGCATCCACCCCGACGGC
CGAGTTGACGGGGTCCGGGAGAAGAGCGACCCTCACATCAAGCTACAACTTCAAGCAGAA
GAGAGAGGAGTTGTGTCTATCAAAGGAGTGTGTGCTAACCGTTACCTGGCTATGAAGGAA
GATGGAAGATTACTGGCTTCTAAATGTGTTACGGATGAGTGTTTCTTTTTTGAACGATTG
GAATCTAATAACTACAATACTTACCGGTCAAGGAAATACACCAGTTGGTATGTGGCACTG
AAACGAACTGGGCAGTATAAACTTGGATCCAAAACAGGACCTGGGCAGAAAGCTATACTT
TTTCTTCCAATGTCTGCTAAGAGCTGA
GenBank Gene IDX04431
GeneCard IDNot Available
GenAtlas IDFGF2
HGNC IDHGNC:3676
Chromosome Location4
Locus4q26-q27
References
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