T3DB: Guanine nucleotide-binding protein G(o) subunit alpha

Name	Guanine nucleotide-binding protein G(o) subunit alpha
Synonyms	Not Available
Gene Name	GNAO1
Organism	Human
Amino acid sequence	>lcl\|BSEQ0009093\|Guanine nucleotide-binding protein G(o) subunit alpha MGCTLSAEERAALERSKAIEKNLKEDGISAAKDVKLLLLGAGESGKSTIVKQMKIIHEDG FSGEDVKQYKPVVYSNTIQSLAAIVRAMDTLGIEYGDKERKADAKMVCDVVSRMEDTEPF SAELLSAMMRLWGDSGIQECFNRSREYQLNDSAKYYLDSLDRIGAADYQPTEQDILRTRV KTTGIVETHFTFKNLHFRLFDVGGQRSERKKWIHCFEDVTAIIFCVALSGYDQVLHEDET TNRMHESLMLFDSICNNKFFIDTSIILFLNKKDLFGEKIKKSPLTICFPEYTGPNTYEDA AAYIQAQFESKNRSPNKEIYCHMTCATDTNNIQVVFDAVTDIIIANNLRGCGLY
Number of residues	354
Molecular Weight	40050.165
Theoretical pI	Not Available
GO Classification	Functions signal transducer activity GTP binding GTPase activity G-protein beta/gamma-subunit complex binding corticotropin-releasing hormone receptor 1 binding metal ion binding mu-type opioid receptor binding G-protein coupled serotonin receptor binding Processes locomotory behavior positive regulation of GTPase activity neuron projection development aging adenylate cyclase-modulating G-protein coupled receptor signaling pathway response to cytokine forebrain development regulation of heart contraction response to drug muscle contraction response to morphine negative regulation of calcium ion transport dopamine receptor signaling pathway response to hydrogen peroxide Components dendrite plasma membrane heterotrimeric G-protein complex myelin sheath
General Function	Signal transducer activity
Specific Function	Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(o) protein function is not clear. Stimulated by RGS14.
Pfam Domain Function	G-alpha (PF00503 )
Transmembrane Regions	Not Available
GenBank Protein ID	Not Available
UniProtKB ID	P09471
UniProtKB Entry Name	GNAO_HUMAN
Cellular Location	Cell membrane
Gene sequence	>lcl\|BSEQ0021727\|Guanine nucleotide-binding protein G(o) subunit alpha (GNAO1) ATGGGATGTACTCTGAGCGCAGAGGAGAGAGCCGCCCTCGAGCGGAGCAAGGCGATTGAG AAAAACCTCAAAGAGGATGGCATCAGCGCCGCCAAAGACGTGAAATTACTCCTGCTCGGG GCTGGAGAATCAGGAAAAAGCACCATTGTGAAGCAGATGAAGATCATCCATGAAGATGGC TTCTCCGGAGAAGACGTGAAACAGTACAAGCCTGTTGTCTACAGCAACACTATCCAGTCC CTGGCAGCCATCGTCCGGGCCATGGACACTTTGGGCATCGAATATGGTGATAAGGAGAGA AAGGCTGACGCCAAGATGGTGTGTGATGTGGTGAGTCGGATGGAAGACACCGAGCCCTTC TCTGCAGAGCTGCTTTCTGCCATGATGCGGCTCTGGGGCGACTCAGGAATCCAAGAGTGC TTCAACCGGTCCCGGGAGTATCAGCTCAACGACTCTGCCAAATACTACCTGGACAGCCTG GATCGGATTGGGGCCGCCGACTACCAGCCCACCGAGCAGGACATCCTCCGAACCAGGGTC AAAACCACTGGCATCGTAGAAACCCACTTCACATTCAAGAACCTCCACTTCAGGCTGTTT GACGTCGGAGGCCAGCGATCTGAACGCAAGAAGTGGATCCATTGCTTCGAGGACGTCACG GCCATCATTTTCTGTGTCGCGCTCAGCGGCTATGACCAGGTGCTCCACGAAGACGAAACC ACGAACCGCATGCACGAGTCTCTCATGCTCTTCGACTCCATCTGTAACAACAAGTTCTTC ATCGATACCTCCATCATTCTCTTCCTCAACAAGAAAGATCTCTTTGGCGAGAAGATCAAG AAGTCACCTTTGACCATCTGCTTTCCTGAATACACAGGCCCCAATACCTATGAAGACGCA GCCGCCTACATCCAAGCACAATTTGAAAGCAAAAACCGCTCACCCAACAAAGAAATATAT TGTCACATGACTTGTGCCACAGACACGAATAACATCCAGGTGGTGTTCGACGCCGTCACC GACATCATCATTGCCAACAACCTCCGGGGCTGCGGCTTGTACTGA
GenBank Gene ID	Not Available
GeneCard ID	Not Available
GenAtlas ID	Not Available
HGNC ID	HGNC:4389
Chromosome Location	16
Locus	Not Available
References	Tsukamoto T, Toyama R, Itoh H, Kozasa T, Matsuoka M, Kaziro Y: Structure of the human gene and two rat cDNAs encoding the alpha chain of GTP-binding regulatory protein Go: two different mRNAs are generated by alternative splicing. Proc Natl Acad Sci U S A. 1991 Apr 15;88(8):2974-8. 1901650 Lavu S, Clark J, Swarup R, Matsushima K, Paturu K, Moss J, Kung HF: Molecular cloning and DNA sequence analysis of the human guanine nucleotide-binding protein Go alpha. Biochem Biophys Res Commun. 1988 Jan 29;150(2):811-5. 3124840 Duc-Goiran P, Bourgeois C, Mignot TM, Robert B, Tanguy G, Ferre F: Identification and expression of Go1 and Go2 alpha-subunit transcripts in human myometrium in relation to pregnancy. Biol Reprod. 1999 Jun;60(6):1528-35. 10330115 Thinon E, Serwa RA, Broncel M, Brannigan JA, Brassat U, Wright MH, Heal WP, Wilkinson AJ, Mann DJ, Tate EW: Global profiling of co- and post-translationally N-myristoylated proteomes in human cells. Nat Commun. 2014 Sep 26;5:4919. doi: 10.1038/ncomms5919. 25255805 Nakamura K, Kodera H, Akita T, Shiina M, Kato M, Hoshino H, Terashima H, Osaka H, Nakamura S, Tohyama J, Kumada T, Furukawa T, Iwata S, Shiihara T, Kubota M, Miyatake S, Koshimizu E, Nishiyama K, Nakashima M, Tsurusaki Y, Miyake N, Hayasaka K, Ogata K, Fukuda A, Matsumoto N, Saitsu H: De Novo mutations in GNAO1, encoding a Galphao subunit of heterotrimeric G proteins, cause epileptic encephalopathy. Am J Hum Genet. 2013 Sep 5;93(3):496-505. doi: 10.1016/j.ajhg.2013.07.014. Epub 2013 Aug 29. 23993195