NameTropomyosin alpha-1 chain
Synonyms
  • Alpha-tropomyosin
  • C15orf13
  • TMSA
  • Tropomyosin-1
Gene NameTPM1
OrganismHuman
Amino acid sequence
>lcl|BSEQ0049787|Tropomyosin alpha-1 chain
MDAIKKKMQMLKLDKENALDRAEQAEADKKAAEDRSKQLEDELVSLQKKLKGTEDELDKY
SEALKDAQEKLELAEKKATDAEADVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAA
DESERGMKVIESRAQKDEEKMEIQEIQLKEAKHIAEDADRKYEEVARKLVIIESDLERAE
ERAELSEGKCAELEEELKTVTNNLKSLEAQAEKYSQKEDRYEEEIKVLSDKLKEAETRAE
FAERSVTKLEKSIDDLEDELYAQKLKYKAISEELDHALNDMTSI
Number of residues284
Molecular Weight32708.175
Theoretical pINot Available
GO Classification
Functions
  • cytoskeletal protein binding
  • structural constituent of cytoskeleton
  • actin binding
  • actin filament binding
  • structural constituent of muscle
Processes
  • ventricular cardiac muscle tissue morphogenesis
  • negative regulation of vascular smooth muscle cell proliferation
  • positive regulation of cell adhesion
  • regulation of cell shape
  • ruffle organization
  • negative regulation of vascular associated smooth muscle cell migration
  • cytoskeleton organization
  • positive regulation of heart rate by epinephrine
  • positive regulation of stress fiber assembly
  • actin filament organization
  • in utero embryonic development
  • sarcomere organization
  • wound healing
  • muscle filament sliding
  • movement of cell or subcellular component
  • regulation of muscle contraction
  • cardiac muscle contraction
  • negative regulation of cell migration
  • positive regulation of ATPase activity
  • regulation of heart contraction
  • cellular response to reactive oxygen species
  • muscle contraction
Components
  • bleb
  • cytoskeleton
  • muscle thin filament tropomyosin
  • actin cytoskeleton
  • actin filament
  • cytosol
  • sarcomere
  • ruffle membrane
  • filamentous actin
  • stress fiber
General FunctionBinds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments.
Specific FunctionActin binding
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein IDNot Available
UniProtKB IDP09493
UniProtKB Entry NameTPM1_HUMAN
Cellular LocationCytoplasm
Gene sequence
>lcl|BSEQ0049788|Tropomyosin alpha-1 chain (TPM1)
ATGGACGCCATCAAGAAGAAGATGCAGATGCTGAAGCTCGACAAGGAGAACGCCTTGGAT
CGAGCTGAGCAGGCGGAGGCCGACAAGAAGGCGGCGGAAGACAGGAGCAAGCAGCTGGAA
GATGAGCTGGTGTCACTGCAAAAGAAACTCAAGGGCACCGAAGATGAACTGGACAAATAC
TCTGAGGCTCTCAAAGATGCCCAGGAGAAGCTGGAGCTGGCAGAGAAAAAGGCCACCGAT
GCTGAAGCCGACGTAGCTTCTCTGAACAGACGCATCCAGCTGGTTGAGGAAGAGTTGGAT
CGTGCCCAGGAGCGTCTGGCAACAGCTTTGCAGAAGCTGGAGGAAGCTGAGAAGGCAGCA
GATGAGAGTGAGAGAGGCATGAAAGTCATTGAGAGTCGAGCCCAAAAAGATGAAGAAAAA
ATGGAAATTCAGGAGATCCAACTGAAAGAGGCCAAGCACATTGCTGAAGATGCCGACCGC
AAATATGAAGAGGTGGCCCGTAAGCTGGTCATCATTGAGAGCGACCTGGAACGTGCAGAG
GAGCGGGCTGAGCTCTCAGAAGGCCAAGTCCGACAGCTGGAAGAACAATTAAGAATAATG
GATCAGACCTTGAAAGCATTAATGGCTGCAGAGGATAAGTACTCGCAGAAGGAAGACAGA
TATGAGGAAGAGATCAAGGTCCTTTCCGACAAGCTGAAGGAGGCTGAGACTCGGGCTGAG
TTTGCGGAGAGGTCAGTAACTAAATTGGAGAAAAGCATTGATGACTTAGAAGACGAGCTG
TACGCTCAGAAACTGAAGTACAAAGCCATCAGCGAGGAGCTGGACCACGCTCTCAACGAT
ATGACTTCCATGTAA
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:12010
Chromosome Location15
Locus15q22.2
References
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