Nicotinate-nucleotide adenylyltransferase

NameNicotinate-nucleotide adenylyltransferase
Synonyms
  • 2.7.7.18
  • Deamido-NAD(+) diphosphorylase
  • Deamido-NAD(+) pyrophosphorylase
  • NaMN adenylyltransferase
  • Nicotinate mononucleotide adenylyltransferase
Gene NamenadD
OrganismShigella flexneri
Amino acid sequence
>lcl|BSEQ0011856|Nicotinate-nucleotide adenylyltransferase
MKSLQALFGGTFDPVHYGHLKPVETLANLIGLTRVTIIPNNVPPHRPQPEANSVQRKHML
ELAIADKPLFTLDERELKRNAPSYTAQTLKEWRQEQGPDVPLAFIIGQDSLLTFPTWYEY
ETILDNAHLIVCRRPGYPLEMAQPQYQQWLEDHLTHNPEDLHLQPAGKIYLAETPWFNIS
ATIIRERLQNGESCEDLLPEPVLTYINQQGLYR
Number of residues213
Molecular Weight24527.75
Theoretical pI5.54
GO Classification
Functions
  • ATP binding
  • nicotinate-nucleotide adenylyltransferase activity
Processes
  • NAD biosynthetic process
General FunctionNicotinate-nucleotide adenylyltransferase activity
Specific FunctionCatalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein IDNot Available
UniProtKB IDP0A753
UniProtKB Entry NameNADD_SHIFL
Cellular LocationNot Available
Gene sequence
>lcl|BSEQ0011857|Nicotinate-nucleotide adenylyltransferase (nadD)
ATGAAATCTTTACAGGCTCTGTTTGGCGGCACCTTTGATCCGGTGCACTATGGTCATCTA
AAACCCGTGGAAACGCTGGCGAATTTGATTGGTCTGACGCGGGTCACAATCATCCCTAAT
AATGTTCCTCCGCATCGTCCCCAGCCGGAAGCGAACAGCGTGCAGCGTAAACACATGCTT
GAACTGGCGATTGCCGACAAGCCATTATTTACTCTTGATGAACGCGAGCTAAAGCGCAAT
GCCCCCTCTTACACTGCGCAAACACTGAAAGAGTGGCGGCAGGAACAAGGACCGGACGTG
CCGCTGGCGTTTATTATTGGTCAGGATTCATTGCTGACCTTTCCGACCTGGTACGAATAC
GAAACGATACTCGACAATGCACATTTGATCGTCTGTCGGCGTCCAGGTTACCCACTTGAA
ATGGCGCAACCGCAATACCAGCAATGGCTGGAAGATCATTTGACACATAACCCGGAAGAT
CTTCACCTTCAGCCTGCCGGTAAAATTTATCTGGCTGAAACGCCGTGGTTTAACATCTCG
GCGACCATCATCCGCGAACGTTTGCAAAACGGTGAATCGTGTGAGGATTTATTGCCGGAA
CCGGTATTGACTTACATTAACCAACAAGGCTTGTATCGCTGA
GenBank Gene IDAE005674
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDNot Available
Chromosome LocationNot Available
LocusNot Available
References
  1. Jin Q, Yuan Z, Xu J, Wang Y, Shen Y, Lu W, Wang J, Liu H, Yang J, Yang F, Zhang X, Zhang J, Yang G, Wu H, Qu D, Dong J, Sun L, Xue Y, Zhao A, Gao Y, Zhu J, Kan B, Ding K, Chen S, Cheng H, Yao Z, He B, Chen R, Ma D, Qiang B, Wen Y, Hou Y, Yu J: Genome sequence of Shigella flexneri 2a: insights into pathogenicity through comparison with genomes of Escherichia coli K12 and O157. Nucleic Acids Res. 2002 Oct 15;30(20):4432-41. 12384590
  2. Wei J, Goldberg MB, Burland V, Venkatesan MM, Deng W, Fournier G, Mayhew GF, Plunkett G 3rd, Rose DJ, Darling A, Mau B, Perna NT, Payne SM, Runyen-Janecky LJ, Zhou S, Schwartz DC, Blattner FR: Complete genome sequence and comparative genomics of Shigella flexneri serotype 2a strain 2457T. Infect Immun. 2003 May;71(5):2775-86. 12704152